ArticleGenetics2015
A novel role for the zinc-finger transcription factor EGL-46 in the differentiation of gas-sensing neurons in Caenorhabditis elegans.
Article in Genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- A gene expression atlas of a juvenile nervous system.bioRxiv : the preprint server for biology · 2025Article
- Characterization of the Doublesex/MAB-3 transcription factor DMD-9 in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2023Article
- Distinct neuropeptide-receptor modules regulate a sex-specific behavioral response to a pheromone.Communications biology · 2021Article
- Transcription Factors That Control Behavior-Lessons FromFrontiers in neuroscience · 2021Review
- Development of specialized sensory neurons engages a nuclear receptor required for functional plasticity.Genes & development · 2020Article
- A single amino acid change in the EGL-46 transcription factor causes defects in BAG neuron specification.microPublication biology · 2020Article
- Repression of an activity-dependent autocrine insulin signal is required for sensory neuron development inDevelopment (Cambridge, England) · 2019Article
- Lineage context switches the function of aDevelopment (Cambridge, England) · 2019Article
- Behavioral Assays to Study Oxygen and Carbon Dioxide Sensing inBio-protocol · 2018Article
- Separate transcriptionally regulated pathways specify distinct classes of sister dendrites in a nociceptive neuron.Developmental biology · 2017Article
- LIN-32/Atonal Controls Oxygen Sensing Neuron Development in Caenorhabditis elegans.Scientific reports · 2017Article
- Control of Neuropeptide Expression by Parallel Activity-dependent Pathways in Caenorhabditis elegans.Scientific reports · 2017Article
- A map of terminal regulators of neuronal identity in Caenorhabditis elegans.Wiley interdisciplinary reviews. Developmental biology · 2016Review
- Toll-like Receptor Signaling Promotes Development and Function of Sensory Neurons Required for a C. elegans Pathogen-Avoidance Behavior.Current biology : CB · 2015Article
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4 authors at 1 institution in 1 country.
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Abstract
Oxygen (O2) and carbon dioxide (CO2) provoke distinct olfactory behaviors via specialized sensory neurons across metazoa. In the nematode C. elegans, the BAG sensory neurons are specialized to sense changes in both O2 and CO2 levels in the environment. The precise functionality of these neurons is specified by the coexpression of a membrane-bound receptor-type guanylyl cyclase GCY-9 that is required for responses to CO2 upshifts and the soluble guanylyl cyclases GCY-31 and GCY-33 that mediate responses to downshifts in O2. Expression of these gas-sensing molecules in the BAG neurons is partially, although not completely, controlled by ETS-5, an ETS-domain-containing transcription factor, and EGL-13, a Sox transcription factor. We report here the identification of EGL-46, a zinc-finger transcription factor, which regulates BAG gas-sensing fate in partially parallel pathways to ETS-5 and EGL-13. Thereby, three conserved transcription factors collaborate to ensure neuron type-specific identity features of the BAG gas-sensing neurons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.