ArticleNeuro-oncology2015
White matter compromise predicts poor intellectual outcome in survivors of pediatric low-grade glioma.
Open access · bronzeAbstract read
In one paragraph
Article in Neuro-oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 10% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Childhood Brain Tumors: a Systematic Review of the Structural Neuroimaging Literature.Neuropsychology review · 2017Pooled it
- Long-term quality of survival after pediatric low-grade glioma.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Review
- Considering Functional Outcomes as Efficacy Endpoints in Pediatric Low-Grade Glioma Clinical Trials: An FDA Educational Symposium.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024Article
- Multimodal imaging with magnetization transfer and diffusion tensor imaging reveals evidence of myelin damage in children and youth treated for a brain tumor.Neuro-oncology practice · 2024Article
- The anatomy of neuroepithelial tumours.Brain : a journal of neurology · 2023Article
- Article
- Structural networking of the developing brain: from maturation to neurosurgical implications.Frontiers in neuroanatomy · 2023Review
- Chronic pediatric diseases and risk for reading difficulties: a narrative review with recommendations.Pediatric research · 2022Review
- Involvement of White Matter Language Tracts in Glioma: Clinical Implications, Operative Management, and Functional Recovery After Injury.Frontiers in neuroscience · 2022Review
- An Integrated Analysis of Clinical, Genomic, and Imaging Features Reveals Predictors of Neurocognitive Outcomes in a Longitudinal Cohort of Pediatric Cancer Survivors, Enriched with CNS Tumors (Rad ART Pro).Frontiers in oncology · 2022Article
- Central Nervous System Plasticity Influences Language and Cognitive Recovery in Adult Glioma.Neurosurgery · 2021Review
- Brain Imaging in Pediatric Cancer Survivors: Correlates of Cognitive Impairment.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2021Review
- Cognitive Risk in Survivors of Pediatric Brain Tumors.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2021Review
- Neurodevelopmental consequences of pediatric cancer and its treatment: applying an early adversity framework to understanding cognitive, behavioral, and emotional outcomes.Neuropsychology review · 2018Review
- 2016 Children's Tumor Foundation conference on neurofibromatosis type 1, neurofibromatosis type 2, and schwannomatosis.American journal of medical genetics. Part A · 2018Article
- Repairing the brain with physical exercise: Cortical thickness and brain volume increases in long-term pediatric brain tumor survivors in response to a structured exercise intervention.NeuroImage. Clinical · 2018Article
- Changes in White Matter Microstructure Impact Cognition by Disrupting the Ability of Neural Assemblies to Synchronize.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Abnormalities of structural brain connectivity in pediatric brain tumor survivors.Neuro-oncology advancesArticle
- Long-term cognitive deficits in pediatric low-grade glioma (LGG) survivors reflect pretreatment conditions-report from the German LGG studies.Neuro-oncology advancesArticle
- Neurocognitive deficits in children with chronic health conditions.The American psychologistReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 1 institution in 1 country.
Fang LiuNeurosciences & Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada (F.L., N.S., F.W., D.J.M.); Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada (U.T., E.B.); Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada (U.T., E.B.); Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada (S.L.); Medical Imaging, University of Toronto, Toronto, Ontario, Canada (S.L.); Departments of Oncology and Pediatrics, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada (D.S.); Independent practice, Montréal area, Québec, Canada (M.-E.B.); Department of Psychology, Division of Oncology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada (D.M.); Divisions of Neurology and Oncology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada (J.H.); Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada (J.H., C.F.); Division of Hematology and Oncology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada (C.F.); Division of Ambulatory Care/Oncology, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada (I.M.-P., D.K.); Department of Pediatrics, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada (D.K.); Department of Psychology, The Hospital for Sick Children, Toronto, Ontario, Canada (D.J.M.); Department of Psychology, University of Toronto, Toronto, Ontario, Canada (D.J.M.).
Nadia ScantleburyNeurosciences & Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada (F.L., N.S., F.W., D.J.M.); Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada (U.T., E.B.); Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada (U.T., E.B.); Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada (S.L.); Medical Imaging, University of Toronto, Toronto, Ontario, Canada (S.L.); Departments of Oncology and Pediatrics, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada (D.S.); Independent practice, Montréal area, Québec, Canada (M.-E.B.); Department of Psychology, Division of Oncology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada (D.M.); Divisions of Neurology and Oncology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada (J.H.); Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada (J.H., C.F.); Division of Hematology and Oncology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada (C.F.); Division of Ambulatory Care/Oncology, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada (I.M.-P., D.K.); Department of Pediatrics, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada (D.K.); Department of Psychology, The Hospital for Sick Children, Toronto, Ontario, Canada (D.J.M.); Department of Psychology, University of Toronto, Toronto, Ontario, Canada (D.J.M.).
Uri TaboriNeurosciences & Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada (F.L., N.S., F.W., D.J.M.); Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada (U.T., E.B.); Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada (U.T., E.B.); Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada (S.L.); Medical Imaging, University of Toronto, Toronto, Ontario, Canada (S.L.); Departments of Oncology and Pediatrics, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada (D.S.); Independent practice, Montréal area, Québec, Canada (M.-E.B.); Department of Psychology, Division of Oncology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada (D.M.); Divisions of Neurology and Oncology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada (J.H.); Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada (J.H., C.F.); Division of Hematology and Oncology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada (C.F.); Division of Ambulatory Care/Oncology, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada (I.M.-P., D.K.); Department of Pediatrics, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada (D.K.); Department of Psychology, The Hospital for Sick Children, Toronto, Ontario, Canada (D.J.M.); Department of Psychology, University of Toronto, Toronto, Ontario, Canada (D.J.M.).
Eric BouffetNeurosciences & Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada (F.L., N.S., F.W., D.J.M.); Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada (U.T., E.B.); Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada (U.T., E.B.); Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada (S.L.); Medical Imaging, University of Toronto, Toronto, Ontario, Canada (S.L.); Departments of Oncology and Pediatrics, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada (D.S.); Independent practice, Montréal area, Québec, Canada (M.-E.B.); Department of Psychology, Division of Oncology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada (D.M.); Divisions of Neurology and Oncology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada (J.H.); Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada (J.H., C.F.); Division of Hematology and Oncology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada (C.F.); Division of Ambulatory Care/Oncology, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada (I.M.-P., D.K.); Department of Pediatrics, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada (D.K.); Department of Psychology, The Hospital for Sick Children, Toronto, Ontario, Canada (D.J.M.); Department of Psychology, University of Toronto, Toronto, Ontario, Canada (D.J.M.).
Suzanne LaughlinNeurosciences & Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada (F.L., N.S., F.W., D.J.M.); Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada (U.T., E.B.); Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada (U.T., E.B.); Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada (S.L.); Medical Imaging, University of Toronto, Toronto, Ontario, Canada (S.L.); Departments of Oncology and Pediatrics, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada (D.S.); Independent practice, Montréal area, Québec, Canada (M.-E.B.); Department of Psychology, Division of Oncology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada (D.M.); Divisions of Neurology and Oncology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada (J.H.); Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada (J.H., C.F.); Division of Hematology and Oncology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada (C.F.); Division of Ambulatory Care/Oncology, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada (I.M.-P., D.K.); Department of Pediatrics, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada (D.K.); Department of Psychology, The Hospital for Sick Children, Toronto, Ontario, Canada (D.J.M.); Department of Psychology, University of Toronto, Toronto, Ontario, Canada (D.J.M.).
Douglas StrotherNeurosciences & Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada (F.L., N.S., F.W., D.J.M.); Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada (U.T., E.B.); Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada (U.T., E.B.); Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada (S.L.); Medical Imaging, University of Toronto, Toronto, Ontario, Canada (S.L.); Departments of Oncology and Pediatrics, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada (D.S.); Independent practice, Montréal area, Québec, Canada (M.-E.B.); Department of Psychology, Division of Oncology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada (D.M.); Divisions of Neurology and Oncology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada (J.H.); Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada (J.H., C.F.); Division of Hematology and Oncology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada (C.F.); Division of Ambulatory Care/Oncology, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada (I.M.-P., D.K.); Department of Pediatrics, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada (D.K.); Department of Psychology, The Hospital for Sick Children, Toronto, Ontario, Canada (D.J.M.); Department of Psychology, University of Toronto, Toronto, Ontario, Canada (D.J.M.).
Dina McConnellNeurosciences & Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada (F.L., N.S., F.W., D.J.M.); Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada (U.T., E.B.); Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada (U.T., E.B.); Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada (S.L.); Medical Imaging, University of Toronto, Toronto, Ontario, Canada (S.L.); Departments of Oncology and Pediatrics, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada (D.S.); Independent practice, Montréal area, Québec, Canada (M.-E.B.); Department of Psychology, Division of Oncology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada (D.M.); Divisions of Neurology and Oncology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada (J.H.); Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada (J.H., C.F.); Division of Hematology and Oncology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada (C.F.); Division of Ambulatory Care/Oncology, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada (I.M.-P., D.K.); Department of Pediatrics, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada (D.K.); Department of Psychology, The Hospital for Sick Children, Toronto, Ontario, Canada (D.J.M.); Department of Psychology, University of Toronto, Toronto, Ontario, Canada (D.J.M.).
Juliette HukinNeurosciences & Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada (F.L., N.S., F.W., D.J.M.); Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada (U.T., E.B.); Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada (U.T., E.B.); Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada (S.L.); Medical Imaging, University of Toronto, Toronto, Ontario, Canada (S.L.); Departments of Oncology and Pediatrics, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada (D.S.); Independent practice, Montréal area, Québec, Canada (M.-E.B.); Department of Psychology, Division of Oncology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada (D.M.); Divisions of Neurology and Oncology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada (J.H.); Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada (J.H., C.F.); Division of Hematology and Oncology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada (C.F.); Division of Ambulatory Care/Oncology, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada (I.M.-P., D.K.); Department of Pediatrics, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada (D.K.); Department of Psychology, The Hospital for Sick Children, Toronto, Ontario, Canada (D.J.M.); Department of Psychology, University of Toronto, Toronto, Ontario, Canada (D.J.M.).
Chris FryerNeurosciences & Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada (F.L., N.S., F.W., D.J.M.); Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada (U.T., E.B.); Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada (U.T., E.B.); Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada (S.L.); Medical Imaging, University of Toronto, Toronto, Ontario, Canada (S.L.); Departments of Oncology and Pediatrics, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada (D.S.); Independent practice, Montréal area, Québec, Canada (M.-E.B.); Department of Psychology, Division of Oncology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada (D.M.); Divisions of Neurology and Oncology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada (J.H.); Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada (J.H., C.F.); Division of Hematology and Oncology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada (C.F.); Division of Ambulatory Care/Oncology, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada (I.M.-P., D.K.); Department of Pediatrics, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada (D.K.); Department of Psychology, The Hospital for Sick Children, Toronto, Ontario, Canada (D.J.M.); Department of Psychology, University of Toronto, Toronto, Ontario, Canada (D.J.M.).
Marie-Eve BrièreNeurosciences & Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada (F.L., N.S., F.W., D.J.M.); Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada (U.T., E.B.); Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada (U.T., E.B.); Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada (S.L.); Medical Imaging, University of Toronto, Toronto, Ontario, Canada (S.L.); Departments of Oncology and Pediatrics, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada (D.S.); Independent practice, Montréal area, Québec, Canada (M.-E.B.); Department of Psychology, Division of Oncology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada (D.M.); Divisions of Neurology and Oncology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada (J.H.); Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada (J.H., C.F.); Division of Hematology and Oncology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada (C.F.); Division of Ambulatory Care/Oncology, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada (I.M.-P., D.K.); Department of Pediatrics, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada (D.K.); Department of Psychology, The Hospital for Sick Children, Toronto, Ontario, Canada (D.J.M.); Department of Psychology, University of Toronto, Toronto, Ontario, Canada (D.J.M.).
Isabelle Montour-ProulxNeurosciences & Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada (F.L., N.S., F.W., D.J.M.); Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada (U.T., E.B.); Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada (U.T., E.B.); Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada (S.L.); Medical Imaging, University of Toronto, Toronto, Ontario, Canada (S.L.); Departments of Oncology and Pediatrics, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada (D.S.); Independent practice, Montréal area, Québec, Canada (M.-E.B.); Department of Psychology, Division of Oncology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada (D.M.); Divisions of Neurology and Oncology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada (J.H.); Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada (J.H., C.F.); Division of Hematology and Oncology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada (C.F.); Division of Ambulatory Care/Oncology, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada (I.M.-P., D.K.); Department of Pediatrics, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada (D.K.); Department of Psychology, The Hospital for Sick Children, Toronto, Ontario, Canada (D.J.M.); Department of Psychology, University of Toronto, Toronto, Ontario, Canada (D.J.M.).
Daniel KeeneNeurosciences & Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada (F.L., N.S., F.W., D.J.M.); Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada (U.T., E.B.); Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada (U.T., E.B.); Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada (S.L.); Medical Imaging, University of Toronto, Toronto, Ontario, Canada (S.L.); Departments of Oncology and Pediatrics, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada (D.S.); Independent practice, Montréal area, Québec, Canada (M.-E.B.); Department of Psychology, Division of Oncology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada (D.M.); Divisions of Neurology and Oncology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada (J.H.); Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada (J.H., C.F.); Division of Hematology and Oncology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada (C.F.); Division of Ambulatory Care/Oncology, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada (I.M.-P., D.K.); Department of Pediatrics, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada (D.K.); Department of Psychology, The Hospital for Sick Children, Toronto, Ontario, Canada (D.J.M.); Department of Psychology, University of Toronto, Toronto, Ontario, Canada (D.J.M.).
Frank WangNeurosciences & Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada (F.L., N.S., F.W., D.J.M.); Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada (U.T., E.B.); Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada (U.T., E.B.); Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada (S.L.); Medical Imaging, University of Toronto, Toronto, Ontario, Canada (S.L.); Departments of Oncology and Pediatrics, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada (D.S.); Independent practice, Montréal area, Québec, Canada (M.-E.B.); Department of Psychology, Division of Oncology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada (D.M.); Divisions of Neurology and Oncology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada (J.H.); Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada (J.H., C.F.); Division of Hematology and Oncology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada (C.F.); Division of Ambulatory Care/Oncology, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada (I.M.-P., D.K.); Department of Pediatrics, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada (D.K.); Department of Psychology, The Hospital for Sick Children, Toronto, Ontario, Canada (D.J.M.); Department of Psychology, University of Toronto, Toronto, Ontario, Canada (D.J.M.).
Donald J MabbottNeurosciences & Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada (F.L., N.S., F.W., D.J.M.); Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada (U.T., E.B.); Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada (U.T., E.B.); Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada (S.L.); Medical Imaging, University of Toronto, Toronto, Ontario, Canada (S.L.); Departments of Oncology and Pediatrics, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada (D.S.); Independent practice, Montréal area, Québec, Canada (M.-E.B.); Department of Psychology, Division of Oncology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada (D.M.); Divisions of Neurology and Oncology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada (J.H.); Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada (J.H., C.F.); Division of Hematology and Oncology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada (C.F.); Division of Ambulatory Care/Oncology, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada (I.M.-P., D.K.); Department of Pediatrics, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada (D.K.); Department of Psychology, The Hospital for Sick Children, Toronto, Ontario, Canada (D.J.M.); Department of Psychology, University of Toronto, Toronto, Ontario, Canada (D.J.M.).
Hospital for Sick Children · CA
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhile the impact of cranial radiation on white matter following treatment for pediatric brain tumor has been the focus of many recent studies, the effect of treatment in the absence of radiation has received little attention. The relations between white matter and cognitive outcome have not been explored in patients who have undergone radiation-free treatment. As most patients treated without cranial radiation survive long after their diagnosis, it is critical to identify factors that may impact structural and neurocognitive outcomes.
methodsUsing diffusion tensor imaging, we examined white matter structure in 32 patients with pediatric low-grade glioma (PLGG) (19 with subtentorial location and 13 with supratentorial location) and 32 healthy participants. Indices of intellectual functioning were also evaluated. Radiation was not used to treat this cohort, aged 8-19 years.
resultsWe detected evidence of deficits in IQ and compromised supra- and subtentorial white matter in patients relative to healthy children (P < .05). Compromise of supratentorial white matter mediated the impact of treatment for PLGG on IQ. Greater white matter compromise was observed in patients who presented without multiple symptoms, were treated with biopsy/no surgery, had positive neurofibromatosis 1 status, were younger age at diagnosis, and whose parents had lower levels of education (P < .05).
conclusionsOur findings provide evidence of increased risk of intellectual and white matter compromise in patients treated for PLGG without radiation. We identify a neural origin of cognitive deficit useful for predicting outcome and mitigating long-term adverse effects in pediatric brain tumor patients treated without cranial radiation.
Indexed as
IntelligenceAdolescentAdultBrainChildDiffusion Tensor ImagingFemaleGliomaHumansIntelligence TestsMaleNeuropsychological TestsPrognosisWhite MatterYoung AdultIQlow-grade gliomasubtentorial tumorssupratentorial tumorswhite matter
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