ArticleDevelopment (Cambridge, England)2014
Wnt/β-catenin signaling integrates patterning and metabolism of the insect growth zone.
Article in Development (Cambridge, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Temporal control of RNAi reveals both robust and labile feedback loops in the segmentation clock of the red flour beetle.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A design logic for sequential segmentation across organisms.The FEBS journal · 2023Article
- Review
- Anterior-posterior patterning of segments in Anopheles stephensi offers insights into the transition from sequential to simultaneous segmentation in holometabolous insects.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2023Article
- Transcriptome of the pygmy grasshopperPeerJ · 2023Article
- Molecular signatures of diapause in the Asian longhorned beetle: Gene expression.Current research in insect science · 2023Article
- First Identification and Investigation of piRNAs in the Larval Gut of the Asian Honeybee,Insects · 2022Article
- Persistent Parental RNAi in the BeetleAdvanced genetics (Hoboken, N.J.) · 2022Article
- Silencing ofInternational journal of molecular sciences · 2022Article
- The organizing role of Wnt signaling pathway during arthropod posterior growth.Frontiers in cell and developmental biology · 2022Review
- Time and space in segmentation.Interface focus · 2021Article
- Spatiotemporal variation in cell proliferation patterns during arthropod axial elongation.Scientific reports · 2021Article
- Genome-enabled insights into the biology of thrips as crop pests.BMC biology · 2020Article
- A small set of conserved genes, including sp5 and Hox, are activated by Wnt signaling in the posterior of planarians and acoels.PLoS genetics · 2019Article
- Embryonic expression of priapulid Wnt genes.Development genes and evolution · 2019Article
- Embryonic expression patterns and phylogenetic analysis of panarthropod sox genes: insight into nervous system development, segmentation and gonadogenesis.BMC evolutionary biology · 2018Article
- Evidence for the temporal regulation of insect segmentation by a conserved sequence of transcription factors.Development (Cambridge, England) · 2018Article
- Double abdomen in a short-germ insect: Zygotic control of axis formation revealed in the beetleProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Gene expression analysis of potential morphogen signalling modifying factors in Panarthropoda.EvoDevo · 2018Article
- Antagonism between Hedgehog and Wnt signaling pathways regulates tumorigenicity.Oncology letters · 2017Article
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5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wnt/β-catenin and hedgehog (Hh) signaling are essential for transmitting signals across cell membranes in animal embryos. Early patterning of the principal insect model, Drosophila melanogaster, occurs in the syncytial blastoderm, where diffusion of transcription factors obviates the need for signaling pathways. However, in the cellularized growth zone of typical short germ insect embryos, signaling pathways are predicted to play a more fundamental role. Indeed, the Wnt/β-catenin pathway is required for posterior elongation in most arthropods, although which target genes are activated in this context remains elusive. Here, we use the short germ beetle Tribolium castaneum to investigate two Wnt and Hh signaling centers located in the head anlagen and in the growth zone of early embryos. We find that Wnt/β-catenin signaling acts upstream of Hh in the growth zone, whereas the opposite interaction occurs in the head. We determine the target gene sets of the Wnt/β-catenin and Hh pathways and find that the growth zone signaling center activates a much greater number of genes and that the Wnt and Hh target gene sets are essentially non-overlapping. The Wnt pathway activates key genes of all three germ layers, including pair-rule genes, and Tc-caudal and Tc-twist. Furthermore, the Wnt pathway is required for hindgut development and we identify Tc-senseless as a novel hindgut patterning gene required in the early growth zone. At the same time, Wnt acts on growth zone metabolism and cell division, thereby integrating growth with patterning. Posterior Hh signaling activates several genes potentially involved in a proteinase cascade of unknown function.
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