ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2015
Essential nutrient supplementation prevents heritable metabolic disease in multigenerational intrauterine growth-restricted rats.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Initiation of metformin in early pregnancy results in fetal bioaccumulation, growth restriction, and renal dysmorphology in a primate model.American journal of obstetrics and gynecology · 2024Article
- On the Relationship between Diabetes and Obstructive Sleep Apnea: Evolution and Epigenetics.Biomedicines · 2022Review
- Maternal and early life exposures and their potential to influence development of the microbiome.Genome medicine · 2022Review
- Developmental origins of metabolic diseases.Physiological reviews · 2021Review
- Interaction between Metformin, Folate and Vitamin BInternational journal of molecular sciences · 2021Review
- Perinatal Nutritional and Metabolic Pathways: Early Origins of Chronic Lung Diseases.Frontiers in medicine · 2021Review
- Effect of diet in females (F1) from prenatally undernourished mothers on metabolism and liver function in the F2 progeny is sex-specific.European journal of nutrition · 2019Article
- Programmed Epigenetic DNA Methylation-Mediated Reduced Neuroprogenitor Cell Proliferation and Differentiation in Small-for-Gestational-Age Offspring.Neuroscience · 2019Article
- Increases in bioactive lipids accompany early metabolic changes associated with β-cell expansion in response to short-term high-fat diet.American journal of physiology. Endocrinology and metabolism · 2018Article
- Perinatal high fat diet and early life methyl donor supplementation alter one carbon metabolism and DNA methylation in the brain.Journal of neurochemistry · 2018Article
- Epigenetic effects of the pregnancy Mediterranean diet adherence on the offspring metabolic syndrome markers.Journal of physiology and biochemistry · 2017Review
- Methyl donor supplementation alters cognitive performance and motivation in female offspring from high-fat diet-fed dams.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Sex-Specific Muscular Maturation Responses Following Prenatal Exposure to Methylation-Related Micronutrients in Pigs.Nutrients · 2017Article
- Developmental Origins of Common Disease: Epigenetic Contributions to Obesity.Annual review of genomics and human genetics · 2016Review
- Alterations in expression of imprinted genes from the H19/IGF2 loci in a multigenerational model of intrauterine growth restriction (IUGR).American journal of obstetrics and gynecology · 2016Article
- Transgenerational Glucose Intolerance of Tumor Necrosis Factor with Epigenetic Alteration in Rat Perirenal Adipose Tissue Induced by Intrauterine Hyperglycemia.Journal of diabetes research · 2016Article
- Heritable IUGR and adult metabolic syndrome are reversible and associated with alterations in the metabolome following dietary supplementation of 1-carbon intermediates.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- The growing problem of obesity: mechanisms, consequences, and therapeutic approaches.Arteriosclerosis, thrombosis, and vascular biology · 2015Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Intrauterine growth restriction (IUGR) confers heritable alterations in DNA methylation, rendering risk of adult metabolic syndrome (MetS). Because CpG methylation is coupled to intake of essential nutrients along the one-carbon pathway, we reasoned that essential nutrient supplementation (ENS) may abrogate IUGR-conferred multigenerational MetS. Pregnant Sprague-Dawley rats underwent bilateral uterine artery ligation causing IUGR in F1. Among the F2 generation, IUGR lineage rats were underweight at birth (6.7 vs. 8.0 g, P < 0.0001) and obese by adulthood (p160: 613 vs. 510 g; P < 0.0001). Dual energy X-ray absorptiometry studies revealed increased central fat mass (Δ+40 g), accompanied by dyslipidemic (>30% elevated, P < 0.05) serum triglycerides (139 mg/dl), very-LDLs (27.8 mg/dl), and fatty acids (632 µM). Hyperglycemic-euglycemic clamp studies and glucose tolerance testing revealed insulin resistance. Conversely, IUGR lineage ENS-fed rats did not manifest MetS, with significantly lower body weight (p160: 410 g), >5-fold less central fat mass, normal hepatic glucose efflux, and >70% reduced circulating triglycerides and very-LDLs compared with IUGR control-fed F2 offspring (P < 0.01). Moreover, increased methylation of the IGF-1 P2 transcriptional start site among IUGR lineage F2 offspring was reversed in ENS (P < 0.04). This is an initial demonstration that supplementation along the one-carbon pathway abrogates adult morbidity and associated epigenomic modifications of IGF-1 in a rodent model of multigenerational MetS.
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