ArticleJournal of leukocyte biology2015
Lymphocytic choriomeningitis virus persistence promotes effector-like memory differentiation and enhances mucosal T cell distribution.
Article in Journal of leukocyte biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 58 citations in OpenAlex.
- Tissue-resident-like CD4+ T cells secreting IL-17 control Mycobacterium tuberculosis in the human lung.The Journal of clinical investigation · 2021Trial
- A gavage-fomite based method to generate mouse models with natural microbiota.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- A host-adapted commensal fungus from pet store mice drives type 2 immunity and cross-kingdom protection.iScience · 2026Article
- A gavage-fomite based method to generate mouse models with natural microbiota.bioRxiv : the preprint server for biology · 2026Article
- Temporal Dissection of TGF-β signaling reveals differential impact during female reproductive mucosal CD8 resident memory T cell differentiation.Mucosal immunology · 2026Article
- Tissue-resident memory T cells in organ transplantation: implications for immune homeostasis and graft outcomes.Inflammation and regeneration · 2026Review
- A host-adapted commensal fungus from pet store mice drives type 2 immunity and cross-kingdom protection.bioRxiv : the preprint server for biology · 2026Article
- Metabolomic profiling reveals the potential of fatty acids as regulators of exhausted CD8 T cells during chronic viral infection.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Tissue-resident exhausted and memory CD8Nature immunology · 2026Article
- Divergent ontogeny of Tissue Resident Memory and Tissue Resident Exhausted CD8bioRxiv : the preprint server for biology · 2025Article
- Resident memory T cell development is gradual and shows AP-1 gene expression in mature cells.JCI insight · 2025Article
- Autoimmunity-associated allele of tyrosine phosphatase gene PTPN22 enhances anti-viral immunity.PLoS pathogens · 2024Article
- T cell receptor signaling strength establishes the chemotactic properties of effector CD8Nature communications · 2023Article
- Small intestine and colon tissue-resident memory CD8Immunity · 2023Article
- Tumor-resident memory T cells as a biomarker of the response to cancer immunotherapy.Frontiers in immunology · 2023Review
- Concomitant immunity to M. tuberculosis infection.Scientific reports · 2022Article
- Novel Lymphocytic Choriomeningitis Virus Strain Sustains Abundant Exhausted Progenitor CD8 T Cells without Systemic Viremia.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Tissue-resident memory T cells in the kidney.Seminars in immunopathology · 2022Review
- Decoding Tissue-Residency: Programming and Potential of Frontline Memory T Cells.Cold Spring Harbor perspectives in biology · 2021Review
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8 authors at 1 institution in 1 country.
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Abstract
Vaccines are desired that maintain abundant memory T cells at nonlymphoid sites of microbial exposure, where they may be anatomically positioned for immediate pathogen interception. Here, we test the impact of antigen persistence on mouse CD8 and CD4 T cell distribution and differentiation by comparing responses to infections with different strains of LCMV that cause either acute or chronic infections. We used in vivo labeling techniques that discriminate between T cells present within tissues and abundant populations that fail to be removed from vascular compartments, despite perfusion. LCMV persistence caused up to ∼30-fold more virus-specific CD8 T cells to distribute to the lung compared with acute infection. Persistent infection also maintained mucosal-homing α4β7 integrin expression, higher granzyme B expression, alterations in the expression of the TRM markers CD69 and CD103, and greater accumulation of virus-specific CD8 T cells in the large intestine, liver, kidney, and female reproductive tract. Persistent infection also increased LCMV-specific CD4 T cell quantity in mucosal tissues and induced maintenance of CXCR4, an HIV coreceptor. This study clarifies the relationship between viral persistence and CD4 and CD8 T cell distribution and mucosal phenotype, indicating that chronic LCMV infection magnifies T cell migration to nonlymphoid tissues.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.