ReviewCold Spring Harbor perspectives in biology2014
Emerging principles governing signal transduction by pattern-recognition receptors.
Review in Cold Spring Harbor perspectives in biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Review
- RAPIDASH: Tag-free enrichment of ribosome-associated proteins reveals composition dynamics in embryonic tissue, cancer cells, and macrophages.Molecular cell · 2024Article
- Gender Control of Mouse Embryos by Activation of TLR7/8 on X Sperm via Ligands dsRNA-40 and dsRNA-DR.Molecules (Basel, Switzerland) · 2024Article
- RAPIDASH: A tag-free enrichment of ribosome-associated proteins reveals compositional dynamics in embryonic tissues and stimulated macrophages.bioRxiv : the preprint server for biology · 2023Article
- Immune Functions of Astrocytes in Viral Neuroinfections.International journal of molecular sciences · 2023Review
- Viral-induced neuroinflammation: Different mechanisms converging to similar exacerbated glial responses.Frontiers in neuroscience · 2023Review
- Targeting epigenetic regulators for inflammation: Mechanisms and intervention therapy.MedComm · 2022Review
- The Interplay between Viruses and Host DNA Sensors.Viruses · 2022Review
- Standardized Whole Blood Assay and Bead-Based Cytokine Profiling Reveal Commonalities and Diversity of the Response to Bacteria and TLR Ligands in Cattle.Frontiers in immunology · 2022Article
- The role of lncRNAs in innate immunity and inflammation.RNA biology · 2021Review
- I'm Infected, Eat Me! Innate Immunity Mediated by Live, Infected Cells Signaling To Be Phagocytosed.Infection and immunity · 2021Review
- Malassezia spp. induce inflammatory cytokines and activate NLRP3 inflammasomes in phagocytes.Journal of leukocyte biology · 2021Article
- Regulation of Tripartite Motif-Containing Proteins on Immune Response and Viral Evasion.Frontiers in microbiology · 2021Review
- Nutraceutical Compounds Targeting Inflammasomes in Human Diseases.International journal of molecular sciences · 2020Review
- Asymmetric distribution of TLR3 leads to a polarized immune response in human intestinal epithelial cells.Nature microbiology · 2020Article
- The NLRP3 inflammasome is involved with the pathogenesis of Mayaro virus.PLoS pathogens · 2019Article
- Saturation of acyl chains converts cardiolipin from an antagonist to an activator of Toll-like receptor-4.Cellular and molecular life sciences : CMLS · 2019Article
- The Expression of Dectin-1, Irak1 and Rip2 During the Host Response to Aspergillus fumigatus.Mycopathologia · 2018Article
- Intracellular Antiviral Immunity.Advances in virus research · 2018Review
- BAD-LAMP controls TLR9 trafficking and signalling in human plasmacytoid dendritic cells.Nature communications · 2017Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The problem of recognizing and disposing of non-self-organisms, whether for nutrients or defense, predates the evolution of multicellularity. Accordingly, the function of the innate immune system is often intimately associated with fundamental aspects of cell biology. Here, we review our current understanding of the links between cell biology and pattern-recognition receptors of the innate immune system. We highlight the importance of receptor localization for the detection of microbes and for the initiation of antimicrobial signaling pathways. We discuss examples that illustrate how pattern-recognition receptors influence, and are influenced by, the general membrane trafficking machinery of mammalian cells. In the future, cell biological analysis likely will rival pure genetic analysis as a tool to uncover fundamental principles that govern host-microbe interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.