ArticleParasitology research2015
The larvicidal activity of Agave sisalana against L4 larvae of Aedes aegypti is mediated by internal necrosis and inhibition of nitric oxide production.
Article in Parasitology research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 28 citations in OpenAlex.
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- Piper capitarianum essential oil: a promising insecticidal agent for the management of Aedes aegypti and Aedes albopictus.Environmental science and pollution research international · 2021Article
- Larvicidal Activity of Cinnamic Acid Derivatives: Investigating Alternative Products forMolecules (Basel, Switzerland) · 2020Article
- Insights on the Larvicidal Mechanism of Action of Fractions and Compounds from Aerial Parts ofMolecules (Basel, Switzerland) · 2020Article
- Larvicidal Compounds Extracted fromMolecules (Basel, Switzerland) · 2019Article
- Green Synthesis of Ag/Ag₂O Nanoparticles Using Aqueous Leaf Extract of Eupatorium odoratum and Its Antimicrobial and Mosquito Larvicidal Activities.Molecules (Basel, Switzerland) · 2017Article
- Inhibitory Effects of Amorphigenin on the Mitochondrial Complex I of Culex pipiens pallens Coquillett (Diptera: Culicidae).International journal of molecular sciences · 2015Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dengue is a viral disease that affects about 50 million people per year around the world. The aim of this study was to investigate the larvicidal activity of Agave sisalana crude extract in order to develop a new insecticide against Aedes aegypti. In larvicidal activity assays, fourth-stage Ae. aegypti larvae were exposed to different concentrations of A. sisalana crude extract for 3, 6, 12, and 24 h for determining the LC50. Next, we explored its cytotoxic activity by flow cytometry. Furthermore, histological alterations were confirmed by histopathological analysis, and the nitric oxide (NO) production by hemocytes was checked after different periods of exposure to A. sisalana crude extract. The LC50 was 4.5 ± 0.07 mg/mL. In addition, flow cytometry revealed an increase of cellular necrosis (21 and 16.5 % after 12 and 24 h, respectively) in larvae that were exposed to A. sisalana crude extract. The histological analysis revealed cell lysis and destruction of the peritrophic membrane. Furthermore, there was a reduction in the concentration of NO in the hemolymph from larvae exposed to A. sisalana crude extract after 3, 6, and 24 h (5.3 ± 4.3 vs. 22.7 ± 5.2 μM, 4.3 ± 5.5 vs. 25.4 ± 6.6 μM, and 6 ± 1.7 vs. 37.1 ± 7.8 μM, respectively). Our findings show that A. sisalana crude extract constitutes an effective larvicidal agent against Ae. aegypti larvae due to its necrotizing activity in hemocytes and inhibition of the NO production.
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