ArticleJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2015
Synergistic effects of acute warming and low pH on cellular stress responses of the gilthead seabream Sparus aurata.
Article in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Responses of marine trophic levels to the combined effects of ocean acidification and warming.Nature communications · 2024Pooled it
- Role of Antioxidant Systems and Heat Shock Response in Aquatic Animals Under Multistress Conditions.Antioxidants (Basel, Switzerland) · 2026Review
- Temperature regulated nutrient sensing and metabolism of amino acids in juvenile turbot (Marine life science & technology · 2025Article
- Treatment with crocin attenuates cardiac metabolic disturbances and subsequent inflammation in streptozotocin-induced diabetes.Molecular and cellular biochemistry · 2025Article
- Effect of Rearing, Physiological, and Processing Conditions on the Volatile Profile of Atlantic Salmon (Foods (Basel, Switzerland) · 2025Article
- Unraveling the metabolic gene expression and energetic patterns of the seasonally acclimatized gilthead seabream.Fish physiology and biochemistry · 2025Article
- Neuromolecular responses in disrupted mutualistic cleaning interactions under future environmental conditions.BMC biology · 2023Article
- Thermal Stress Induces Metabolic Responses in Juvenile Qingtian Paddy Field CarpAnimals : an open access journal from MDPI · 2022Article
- Metabolic scope, performance and tolerance of juvenile European sea bass Dicentrarchus labrax upon acclimation to high temperatures.PloS one · 2022Article
- DietaryAquaculture nutrition · 2022Article
- Energetic, antioxidant, inflammatory and cell death responses in the red muscle of thermally stressed Sparus aurata.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2020Article
- Effect of water temperature on cellular stress responses in meagre (Argyrosomus regius).Fish physiology and biochemistry · 2020Article
- Physio-metabolic response of rainbow trout during prolonged food deprivation before slaughter.Fish physiology and biochemistry · 2019Article
- The impact of acute thermal stress on the metabolome of the black rockfish (Sebastes schlegelii).PloS one · 2019Article
- Come rain or come shine: environmental effects on the infective stages of Sparicotyle chrysophrii, a key pathogen in Mediterranean aquaculture.Parasites & vectors · 2018Article
- Somatotropic Axis Regulation Unravels the Differential Effects of Nutritional and Environmental Factors in Growth Performance of Marine Farmed Fishes.Frontiers in endocrinology · 2018Review
- Redox Challenge in a Cultured Temperate Marine Species During Low Temperature and Temperature Recovery.Frontiers in physiology · 2018Article
- Contrasting impacts of ocean acidification and warming on the molecular responses of COBMC genomics · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study assesses the resilience of the Mediterranean gilthead seabream (Sparus aurata) to acute warming and water acidification, using cellular indicators of systemic to molecular responses to various temperatures and CO2 concentrations. Tissue metabolic capacity derived from enzyme measurements, citrate synthase, 3-hydroxyacyl CoA dehydrogenase (HOAD), as well as lactate dehydrogenase. Cellular stress and signaling responses were identified from expression patterns of Hsp70 and Hsp90, the phosphorylation of p38 MAPK, JNKs and ERKs, from protein ubiquitylation and finally from the levels of transcription factor Hif-1α as an indicator of systemic hypoxemia. Exposure to elevated CO2 levels at temperatures higher than 24 °C generally caused an increase in fish mortality above the rate caused by warming alone, indicating effects of the two factors and a failure of acclimation and thus the limits of phenotypic plasticity to be reached. As a potential reason, tissue-dependent induction and stabilization of Hif-1α indicate hypoxemic conditions. Their exacerbation by enhanced CO2 levels is linked to the persistent expression of Hsp70 and Hsp90, oxidative stress and activation of MAPK and ubiquitin pathways. Antioxidant defence is enhanced by expression of catalase and glutathione reductase, however, leaving superoxide dismutase suppressed by elevated CO2 levels. On longer timescales in specimens surviving warming and CO2 exposures, various metabolic adjustments initiate a preference to oxidize lipid via HOAD for energy supply. These processes indicate significant acclimation up to a limit and a time-limited capacity to survive extreme conditions passively by exploiting mechanisms of cellular resilience.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.