ReviewJournal of neural transmission (Vienna, Austria : 1996)2015
Heterogeneity and individuality: microRNAs in mental disorders.
Review in Journal of neural transmission (Vienna, Austria : 1996), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- Review
- Epigenetics of Fear, Anxiety and Stress - Focus on Histone Modifications.Current neuropharmacology · 2024Article
- The role of epigenetics in anxiety disorders.Molecular biology reports · 2023Review
- Polymorphisms in MicroRNA Genes Associated with Schizophrenia Susceptibility but Not with Effectiveness of MECT.Computational and mathematical methods in medicine · 2021Article
- Rac1 relieves neuronal injury induced by oxygenglucose deprivation and re-oxygenation via regulation of mitochondrial biogenesis and function.Neural regeneration research · 2020Article
- The Computational Analysis Conducted on miRNA Target Sites in Association with SNPs at 3'UTR of ADHD-implicated Genes.Central nervous system agents in medicinal chemistry · 2020Article
- Screening of schizophrenia associated miRNAs and the regulation of miR-320a-3p on integrin β1.Medicine · 2019Article
- Improving Bioinformatics Prediction of microRNA Targets by Ranks Aggregation.Frontiers in genetics · 2019Article
- mirDIP 4.1-integrative database of human microRNA target predictions.Nucleic acids research · 2018Article
- Association ofFrontiers in psychiatry · 2018Article
- MicroRNAs as Immunotherapy Targets for Treating Gastroenterological Cancers.Canadian journal of gastroenterology & hepatology · 2018Review
- Large normal-range TBP and ATXN7 CAG repeat lengths are associated with increased lifetime risk of depression.Translational psychiatry · 2017Article
- hsa-miR-4485 regulates mitochondrial functions and inhibits the tumorigenicity of breast cancer cells.Journal of molecular medicine (Berlin, Germany) · 2017Article
- Diagnostic and therapeutic potential of microRNAs in neuropsychiatric disorders: Past, present, and future.Progress in neuro-psychopharmacology & biological psychiatry · 2017Review
- MicroRNA expression profiles in chronic epilepsy rats and neuroprotection from seizures by targeting miR-344a.Neuropsychiatric disease and treatment · 2017Article
- Exacerbation of Mild Hypoxia on Acute Radiation Syndrome and Subsequent Mortality.Adaptive medicine · 2017Article
- Turing Revisited: Decoding the microRNA Messages in Brain Extracellular Vesicles for Early Detection of Neurodevelopmental Disorders.Current environmental health reports · 2016Review
- miRNAs in NMDA receptor-dependent synaptic plasticity and psychiatric disorders.Clinical science (London, England : 1979) · 2016Review
- Pathogenetic and therapeutic applications of microRNAs in major depressive disorder.Progress in neuro-psychopharmacology & biological psychiatry · 2016Review
- Progesterone: a universal stimulus for neuronal cells?Neural regeneration research · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs are about 22 nucleotide long single-stranded RNA molecules, negatively regulating gene expression of a single gene or a gene network. In neural tissues, they have been implicated in developmental and neuroplasticity-related processes, such as neurogenesis, differentiation, apoptosis and long-term potentiation. Their molecular mode of action is reminiscent of findings of genome-wide association studies in mental disorders, unable to attribute the risk of disease to a specific gene, but rather to multiple genes, gene-networks and gene-environment interaction. As such, microRNAs are an attractive target for research. Here, we review clinical studies conducted in humans on microRNAs in mental disorders with a particular focus on schizophrenia, bipolar disorder, major depressive disorder and anxiety disorders. The majority of clinical studies have focused on schizophrenia. The most robust finding has been reported for rs1625579 located in MIR137HG, which was associated with schizophrenia on a genome-wide level. Concerning bipolar disorder, major depression and anxiety disorders, promising results have been published, but only a considerably smaller number of clinical studies is available and genome-wide association studies did not suggest a direct link to microRNAs so far. Expression of microRNAs as biomarkers of mental disorders and treatment response is currently emerging with preliminary results. Larger-scaled genetic and functional studies along with translational research are needed to enhance our understanding of microRNAs in mental disorders. These studies will aid in disentangling the complex genetic nature of these disorders and possibly contribute to the development of novel, individualized diagnostic and therapeutic approaches.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.