ArticleVirchows Archiv : an international journal of pathology2015
Annexin A10 is a marker for the serrated pathway of colorectal carcinoma.
Article in Virchows Archiv : an international journal of pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 53 citations in OpenAlex.
- Trial
- Knockdown of ANXA10 induces ferroptosis by inhibiting autophagy-mediated TFRC degradation in colorectal cancer.Cell death & disease · 2023Article
- A prognostic score based on B cell and plasma cell densities compared to T cell densities in colorectal cancer.International journal of colorectal disease · 2023Article
- An "expressionistic" look at serrated precancerous colorectal lesions.Diagnostic pathology · 2021Article
- Beyond Colonoscopy: Exploring New Cell Surface Biomarkers for Detection of Early, Heterogenous Colorectal Lesions.Frontiers in oncology · 2021Review
- Expression of the Serrated Markers Annexin A10 or Gremlin1 in Colonic Adenocarcinomas: Morphology and Prognostic Values.Pathology oncology research : POR · 2020Article
- Systemic inflammation is associated with circulating cell death released keratin 18 fragments in colorectal cancer.Oncoimmunology · 2020Article
- Platelet count, aspirin use, and characteristics of host inflammatory responses in colorectal cancer.Journal of translational medicine · 2019Article
- ANXA10 induction by interaction with tumor-associated macrophages promotes the growth of esophageal squamous cell carcinoma.Pathology international · 2019Article
- Frequent Alteration of Annexin A9 and A10 in HPV-Negative Head and Neck Squamous Cell Carcinomas: Correlation with the Histopathological Differentiation Grade.Journal of clinical medicine · 2019Article
- Alterations in serum amino-acid profile in the progression of colorectal cancer: associations with systemic inflammation, tumour stage and patient survival.British journal of cancer · 2019Article
- Traditional serrated adenoma: an overview of pathology and emphasis on molecular pathogenesis.BMJ open gastroenterology · 2019Review
- Molecular Profiling Based on KRAS/BRAF Mutation, Methylation, and Microsatellite Statuses in Serrated Lesions.Digestive diseases and sciences · 2018Article
- High-serum MMP-8 levels are associated with decreased survival and systemic inflammation in colorectal cancer.British journal of cancer · 2018Article
- LRP1 expression in colon cancer predicts clinical outcome.Oncotarget · 2018Article
- Preoperative anemia in colorectal cancer: relationships with tumor characteristics, systemic inflammation, and survival.Scientific reports · 2018Article
- Article
- Annexin A10 is a candidate marker associated with the progression of pancreatic precursor lesions to adenocarcinoma.PloS one · 2017Article
- Expression of Annexin A10 in Serrated Polyps Predicts the Development of Metachronous Serrated Polyps.Clinical and translational gastroenterology · 2016Article
- Annexin A10 expression in colorectal cancers with emphasis on the serrated neoplasia pathway.World journal of gastroenterology · 2015Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serrated adenocarcinoma (SAC), representing at least 10 % of colorectal carcinomas (CRC), differs from conventional carcinomas not only by its histology, but also by its molecular basis. However, the diagnosis of SAC in poorly differentiated cases and without an adjacent serrated adenoma can be challenging. In this study, we utilized previously described expression data and identified annexin A10 (ANXA10) as a potential marker for SAC. We conducted ANXA10 immunohistochemistry in groups of 146 CRC patients and 131 serrated and conventional polyps. In CRC cases, ANXA10 expression associated with serrated histology (sensitivity 42 % and specificity 98 %). BRAF V600E mutation correlated with ANXA10 expression but also seven BRAF wild-type tumors (5 %) were positive for ANXA10. Immunoreactivity for either ANXA10 or BRAF V600E was an accurate predictor of serrated histology (sensitivity 55 % and specificity 97 %). ANXA10 expression did not associate with tumor stage or grade. Of the 131 colorectal polyps, 30/30 of sessile serrated adenomas, 6/11 traditional serrated adenomas, 20/32 hyperplastic polyps, and 2/27 tubulovillous adenomas were positive for ANXA10, while 31/31 tubular adenomas were negative. In conclusion, the results suggest that ANXA10 is a marker with high specificity for the serrated pathway of CRC.
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