Evidence map›Paper›PMID 25394828›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2015

NMDA-type glutamate receptors participate in reduction of food intake following hindbrain melanocortin receptor activation.

Carlos A Campos, Robert C Ritter

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Leptin Sensitizes NTS Neurons to Vagal Input by Increasing Postsynaptic NMDA Receptor Currents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
  4. Thrombin action on astrocytes in the hindbrain of the rat disrupts glycemic and respiratory control.American journal of physiology. Regulatory, integrative and comparative physiology · 2020
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Modulatory function of NMDA glutamate receptor on MCVeterinary research communications · 2017
    Article
  10. Review
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Carlos A CamposDepartment of Integrative Physiology and Neuroscience, College of Veterinary Medicine, Washington State University, Pullman, Washington.
Robert C RitterDepartment of Integrative Physiology and Neuroscience, College of Veterinary Medicine, Washington State University, Pullman, Washington britter@vetmed.wsu.edu.
Washington State University · US

Funding

The Role of Glutamate in the Control of Food IntakeR01DK052849 · NIDDK · WASHINGTON STATE UNIVERSITY · PI APPLEYARD, SUZANNE M, RITTER, ROBERT C · 1998 to 2021
$6.3M
NEURAL SUBSTRATES OF PEPTIDE-INDUCED SATIETYR01NS020561 · NINDS · WASHINGTON STATE UNIVERSITY · PI RITTER, ROBERT C · 1985 to 2012
$3.6M
NIDDK NIH HHS DK-52849NIDDK NIH HHS R01 DK052849NINDS NIH HHS NS-20561NINDS NIH HHS R01 NS020561
6 · The paper itself

Abstract

Hindbrain injection of a melanocortin-3/4 receptor agonist, MTII, reduces food intake primarily by reducing meal size. Our previously reported results indicate that N-methyl-D-aspartate-type glutamate receptors (NMDAR) in the nucleus of the solitary tract (NTS) play an important role in the control of meal size and food intake. Therefore, we hypothesized that activation of NTS NMDARs contribute to reduction of food intake in response to fourth ventricle or NTS injection of MTII. We found that coinjection of a competitive NMDAR antagonist (d-CPP-ene) with MTII into the fourth ventricle or directly into the NTS of adult male rats attenuated MTII-induced reduction of food intake. Hindbrain NMDAR antagonism also attenuated MTII-induced ERK1/2 phosphorylation in NTS neurons and prevented synapsin I phosphorylation in central vagal afferent endings, both of which are cellular mechanisms previously shown to participate in hindbrain melanocortinergic reduction of food intake. Together, our results indicate that NMDAR activation significantly contributes to reduction of food intake following hindbrain melanocortin receptor activation, and it participates in melanocortinergic signaling in NTS neural circuits that mediate reduction of food intake.

Indexed as

alpha-MSHAnimalsAppetite RegulationBehavior, AnimalEatingExcitatory Amino Acid AntagonistsInjections, IntraventricularMaleMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Neural PathwaysPhosphorylationRats, Sprague-DawleyReceptors, MelanocortinReceptors, N-Methyl-D-AspartateRhombencephalonacetyl-norleucyl(4)-(aspartyl(5)-histidyl(6)-phenylalanyl(7)-arginyl(8)-tryptophyl(9)-lysyl(10))cyclo-alpha-MSH(4-10)amidealpha-MSHExcitatory Amino Acid AntagonistsMapk1 protein, ratMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Receptors, MelanocortinReceptors, N-Methyl-D-AspartateSynapsinsnucleus of the solitary tractproopiomelanocortinsatiationvagus

Identifiers

PMID25394828
PMCPMC4281681
OpenAlexW2030062192

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.