ArticleNature communications2014
The role of maternal-specific H3K9me3 modification in establishing imprinted X-chromosome inactivation and embryogenesis in mice.
Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 60 citations in OpenAlex.
- Prenatal Androgenization Modifies H3K9me3 Binding in the Promoter of the Androgen Receptor Gene in the Arcuate Nucleus of the Adult Female Mouse.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- Silencing XIST on the future active X: Searching human and bovine preimplantation embryos for the repressor.European journal of human genetics : EJHG · 2024Article
- Paternal impact on the developmental programming of sexual dimorphism.Frontiers in cell and developmental biology · 2024Review
- Review
- Phytochemicals Targeting Oxidative Stress, Interconnected Neuroinflammatory, and Neuroapoptotic Pathways Following Radiation.Current neuropharmacology · 2022Review
- Global Gene Expression Regulation Mediated by TGFβ Through H3K9me3 Mark.Cancer informatics · 2022Article
- Maternal H3K27me3-dependent autosomal and X chromosome imprinting.Nature reviews. Genetics · 2020Review
- Erasing gametes to write blastocysts: metabolism as the new player in epigenetic reprogramming.Animal reproduction · 2020Review
- Bioinformatics analysis of the network of histone H3 lysine 9 trimethylation in acute myeloid leukaemia.Oncology reports · 2020Article
- Integrative Analysis of NSCLC Identifies LINC01234 as an Oncogenic lncRNA that Interacts with HNRNPA2B1 and Regulates miR-106b Biogenesis.Molecular therapy : the journal of the American Society of Gene Therapy · 2020Article
- Epigenetic signatures associated with imprinted paternally expressed genes in the Arabidopsis endosperm.Genome biology · 2019Article
- The Emerging Role of H3K9me3 as a Potential Therapeutic Target in Acute Myeloid Leukemia.Frontiers in oncology · 2019Review
- KDM6A and KDM6B play contrasting roles in nuclear transfer embryos revealed by MERVL reporter system.EMBO reports · 2018Article
- Role of lncRNAs in aging and age-related diseases.Aging medicine (Milton (N.S.W)) · 2018Review
- Reprogramming of H3K9me3-dependent heterochromatin during mammalian embryo development.Nature cell biology · 2018Article
- Long non-coding RNAs involved in the regulatory network during porcine pre-implantation embryonic development and iPSC induction.Scientific reports · 2018Article
- What makes the maternal X chromosome resistant to undergoing imprinted X inactivation?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Genomic imprinting ofGenes & development · 2017Article
- Dosage compensation in the process of inactivation/reactivation during both germ cell development and early embryogenesis in mouse.Scientific reports · 2017Article
- Embryonic loss of human females with partial trisomy 19 identifies region critical for the single active X.PloS one · 2017Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Maintaining a single active X-chromosome by repressing Xist is crucial for embryonic development in mice. Although the Xist activator RNF12/RLIM is present as a maternal factor, maternal Xist (Xm-Xist) is repressed during preimplantation phases to establish imprinted X-chromosome inactivation (XCI). Here we show, using a highly reproducible chromatin immunoprecipitation method that facilitates chromatin analysis of preimplantation embryos, that H3K9me3 is enriched at the Xist promoter region, preventing Xm-Xist activation by RNF12. The high levels of H3K9me3 at the Xist promoter region are lost in embryonic stem (ES) cells, and ES-cloned embryos show RNF12-dependent Xist expression. Moreover, lack of Xm-XCI in the trophectoderm, rather than loss of paternally expressed imprinted genes, is the primary cause of embryonic lethality in 70-80% of parthenogenotes immediately after implantation. This study reveals that H3K9me3 is involved in the imprinting that silences Xm-Xist. Our findings highlight the role of maternal-specific H3K9me3 modification in embryo development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.