Evidence map›Paper›PMID 25394620›Full record

ArticleRheumatology (Oxford, England)2015

Dynamics of syndesmophyte growth in AS as measured by quantitative CT: heterogeneity within and among vertebral disc spaces.

Sovira Tan, Jianhua Yao, John A Flynn, Lawrence Yao, Michael M Ward

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Rheumatology (Oxford, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Syndesmophyte growth in ankylosing spondylitis.Current opinion in rheumatology · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sovira TanNational Institute of Arthritis and Musculoskeletal and Skin Diseases, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda and Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Jianhua YaoNational Institute of Arthritis and Musculoskeletal and Skin Diseases, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda and Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
John A FlynnNational Institute of Arthritis and Musculoskeletal and Skin Diseases, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda and Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Lawrence YaoNational Institute of Arthritis and Musculoskeletal and Skin Diseases, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda and Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Michael M WardNational Institute of Arthritis and Musculoskeletal and Skin Diseases, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda and Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA wardm1@mail.nih.gov.
National Institutes of Health · USJohns Hopkins University · US

Funding

ZINC AND CA EDTA THERAPY OF PLUMBISMM01RR000052 · NCRR · JOHNS HOPKINS UNIVERSITY · PI BELCHER, HAROLYN MILLICENT EDITH · 1985 to 2007
$37.3M
Outcomes in Rheumatic DiseasesZIAAR041153 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI WARD, MICHAEL · 2009 to 2020
$12.6M
Intramural NIH HHSNCRR NIH HHS M01 RR000052NCRR NIH HHS M01-RR00052
6 · The paper itself

Abstract

objectiveSyndesmophytes in AS typically grow slowly, but it is not known whether growth is uniform among syndesmophytes in the same intervertebral disc space (IDS) or among different IDSs in the same patient or if growth is heterogeneous. We examined the dynamics of syndesmophyte growth over 24 months using CT, with the main aim of determining if syndesmophytes in the same IDS or the same patient grow at similar rates.

methodsWe performed lumbar spine CT scans on 33 patients and measured syndesmophytes in four IDSs using a validated computer algorithm. Scans were done at baseline and 12 and 24 months. We compared absolute and percentage changes in volume from baseline to 12 months and to 24 months among syndesmophytes in the same IDS and among four IDSs of each patient. We also examined whether growth among all IDSs differed between study years.

resultsAmong 60 IDSs with at least two syndesmophytes at baseline (range 2-6), there was substantial heterogeneity in both absolute (P < 0.0001) and percentage (P = 0.0002) volume increases among syndesmophytes in the same IDS. Several IDSs had both syndesmophytes with no growth and syndesmophytes that increased by >100 mm(3). Similarly there was significant heterogeneity in syndesmophyte growth among IDSs of individual patients. Increases in total syndesmophyte volume for each patient also tended to differ between study years (P = 0.07).

conclusionSyndesmophytes in AS do not all grow continuously. Rates of growth over 24 months commonly differ between syndesmophytes in the same IDS and between different IDSs in the same patient, suggesting that local factors regulate syndesmophyte growth.

Indexed as

AdultAlgorithmsFemaleHumansIntervertebral DiscLongitudinal StudiesLumbar VertebraeMaleMiddle AgedProspective StudiesSpondylitis, AnkylosingThoracic VertebraeTomography, X-Ray Computedankylosing spondylitiscomputed tomographysyndesmophyte

Identifiers

PMID25394620
PMCPMC4447840
OpenAlexW1983993735

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.