ArticleNature communications2014
Real-time estimation and biofeedback of single-neuron firing rates using local field potentials.
Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Volitional control of single-electrode high gamma local field potentials by people with paralysis.Journal of neurophysiology · 2019Trial
- Super-twisting sliding mode control of dopamine release in VTA dopaminergic neuron model: a simulation study.Scientific reports · 2026Article
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- Unraveling the roles of spatial working memory sustained and selective neurons in prefrontal cortex.Communications biology · 2025Article
- Machine learning-based high-frequency neuronal spike reconstruction from low-frequency and low-sampling-rate recordings.Nature communications · 2024Article
- Closed-loop optogenetic control of the dynamics of neural activity in non-human primates.Nature biomedical engineering · 2023Article
- Emergent Low-Frequency Activity in Cortico-Cerebellar Networks with Motor Skill Learning.eNeuro · 2023Article
- Single-neuron bursts encode pathological oscillations in subcortical nuclei of patients with Parkinson's disease and essential tremor.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Brain signal predictions from multi-scale networks using a linearized framework.PLoS computational biology · 2022Article
- The significance of neural inter-frequency power correlations.Scientific reports · 2021Article
- Inferring entire spiking activity from local field potentials.Scientific reports · 2021Article
- Routing information flow by separate neural synchrony frequencies allows for "functionally labeled lines" in higher primate cortex.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Sequential Neural Activity in Primary Motor Cortex during Sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Linking Pathological Oscillations With Altered Temporal Processing in Parkinsons Disease: Neurophysiological Mechanisms and Implications for Neuromodulation.Frontiers in neurology · 2019Article
- Article
- Low-frequency cortical activity is a neuromodulatory target that tracks recovery after stroke.Nature medicine · 2018Article
- Decoding Local Field Potentials for Neural Interfaces.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2017Review
- Physiological properties of brain-machine interface input signals.Journal of neurophysiology · 2017Review
- A network engineering perspective on probing and perturbing cognition with neurofeedback.Annals of the New York Academy of Sciences · 2017Review
- Artefactual origin of biphasic cortical spike-LFP correlation.Journal of computational neuroscience · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The long-term stability and low-frequency composition of local field potentials (LFPs) offer important advantages for robust and efficient neuroprostheses. However, cortical LFPs recorded by multi-electrode arrays are often assumed to contain only redundant information arising from the activity of large neuronal populations. Here we show that multichannel LFPs in monkey motor cortex each contain a slightly different mixture of distinctive slow potentials that accompany neuronal firing. As a result, the firing rates of individual neurons can be estimated with surprising accuracy. We implemented this method in a real-time biofeedback brain-machine interface, and found that monkeys could learn to modulate the activity of arbitrary neurons using feedback derived solely from LFPs. These findings provide a principled method for monitoring individual neurons without long-term recording of action potentials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.