ArticleGenetics in medicine : official journal of the American College of Medical Genetics2015
Inbreeding among Caribbean Hispanics from the Dominican Republic and its effects on risk of Alzheimer disease.
Article in Genetics in medicine : official journal of the American College of Medical Genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
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- Revealing the secrets of Blue Zones.Frontiers in pharmacology · 2024Review
- Allele and genotype frequencies of variants in P450 cytochromes, transports, and DNA repair enzymes in the Dominican Republic population.Frontiers in pharmacology · 2024Article
- A global view of the genetic basis of Alzheimer disease.Nature reviews. Neurology · 2023Review
- Admixture mapping reveals the association between Native American ancestry at 3q13.11 and reduced risk of Alzheimer's disease in Caribbean Hispanics.Alzheimer's research & therapy · 2021Article
- Dominantly inherited Alzheimer's disease in Latin America: Genetic heterogeneity and clinical phenotypes.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021Observational
- Long runs of homozygosity are associated with Alzheimer's disease.Translational psychiatry · 2021Article
- Quality of Education and Late-Life Cognitive Function in a Population-Based Sample From Puerto Rico.Innovation in aging · 2021Article
- Dementia Research in the Caribbean Hispanic Islands: Present Findings and Future Trends.Frontiers in public health · 2020Article
- Recent Consanguinity and Outbred Autozygosity Are Associated With Increased Risk of Late-Onset Alzheimer's Disease.Frontiers in genetics · 2020Article
- The Puerto Rico Alzheimer Disease Initiative (PRADI): A Multisource Ascertainment Approach.Frontiers in genetics · 2019Article
- Whole genome sequencing of Caribbean Hispanic families with late-onset Alzheimer's disease.Annals of clinical and translational neurology · 2018Article
- Cerebrovascular Disease and Neurodegeneration in Alzheimer's Disease with and without a Strong Family History: A Pilot Magnetic Resonance Imaging Study in Dominican Republic.Journal of Alzheimer's disease : JAD · 2018Article
- Linkage analysis of multiplex Caribbean Hispanic families loaded for unexplained early-onset cases identifies novel Alzheimer's disease loci.Alzheimer's & dementia (Amsterdam, Netherlands) · 2018Article
- Ultra-rare mutations inNeurology. Genetics · 2017Article
- ABCA7 frameshift deletion associated with Alzheimer disease in African Americans.Neurology. Genetics · 2016Article
- Association of Long Runs of Homozygosity With Alzheimer Disease Among African American Individuals.JAMA neurology · 2015Article
- F-box/LRR-repeat protein 7 is genetically associated with Alzheimer's disease.Annals of clinical and translational neurology · 2015Article
- Coding mutations in SORL1 and Alzheimer disease.Annals of neurology · 2015Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 5 countries.
Funding
Abstract
backgroundInbreeding can be associated with a modification of disease risk due to excess homozygosity of recessive alleles affecting a wide range of phenotypes. We estimated the inbreeding coefficient in Caribbean Hispanics and examined its effects on risk of late-onset Alzheimer disease.
methodsThe inbreeding coefficient was calculated in 3,392 subjects (1,451 late-onset Alzheimer disease patients and 1,941 age-matched healthy controls) of Caribbean Hispanic ancestry using 177,997 nearly independent single-nucleotide polymorphisms from genome-wide array. The inbreeding coefficient was estimated using the excess homozygosity method with and without adjusting for admixture.
resultsThe average inbreeding coefficient in Caribbean Hispanics without accounting for admixture was F = 0.018 (±0.048), suggesting a mating equivalent to that of second cousins or second cousins once removed. Adjusting for admixture from three parent populations, the average inbreeding coefficient was found to be 0.0034 (±0.019) or close to third-cousin mating. Inbreeding coefficient was a significant predictor of Alzheimer disease when age, sex, and APOE genotype were used as adjusting covariates (P = 0.03).
conclusionThe average inbreeding coefficient of this population is significantly higher than that of the general Caucasian populations in North America. The high rate of inbreeding resulting in increased frequency of recessive variants is advantageous for the identification of rare variants associated with late-onset Alzheimer disease.Genet Med 17 8, 639-643.
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