ArticleThe European journal of neuroscience2015
Dopamine D2 receptors preferentially regulate the development of light responses of the inner retina.
Article in The European journal of neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- An in-depth characterization of development-related electroretinographical and morphological changes in Landrace pigs.Documenta ophthalmologica. Advances in ophthalmology · 2025Article
- Light drives the developmental progression of outer retinal function.The Journal of general physiology · 2023Article
- Activation of oxytocin receptors in mouse GABAergic amacrine cells modulates retinal dopaminergic signaling.BMC biology · 2022Article
- Blue light blind-spot stimulation upregulates b-wave and pattern ERG activity in myopes.Scientific reports · 2021Article
- Ex vivo electroretinograms made easy: performing ERGs using 3D printed components.The Journal of physiology · 2020Article
- Up-Regulation of SorCS1, an Important Sorting Receptor, in the Retina of a Form-Deprivation Rat Model.Cellular and molecular neurobiology · 2020Article
- Article
- Abundant Neural circRNA Cdr1as Is Not Indispensable for Retina Maintenance.Frontiers in cell and developmental biology · 2020Article
- Do you have restless leg syndrome? I understood from your eyes.Sleep & breathing = Schlaf & Atmung · 2019Article
- The effects of dopamine and dopamine receptor agonists on the phototransduction cascade of frog rods.Molecular vision · 2019Article
- Expression of dopamine D2 and D3 receptors in the human retina revealed by positron emission tomography and targeted mass spectrometry.Experimental eye research · 2018Article
- The Development of Mid-Wavelength Photoresponsivity in the Mouse Retina.Current eye research · 2018Article
- Cloning and functional characterization of the DA2 receptor gene in Chinese mitten crab (Eriocheir sinensis).PloS one · 2018Article
- Contribution of GABAa, GABAc and glycine receptors to rat dark-adapted oscillatory potentials in the time and frequency domain.Oncotarget · 2017Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Retinal light responsiveness measured via electroretinography undergoes developmental modulation, and is thought to be critically regulated by both visual experience and dopamine. The primary goal of this study was to determine whether dopamine D2 receptors regulate the visual experience-dependent functional development of the retina. Accordingly, we recorded electroretinograms from wild-type mice and mice with a genetic deletion of the gene that encodes the D2 receptor raised under normal cyclic light conditions and constant darkness. Our results demonstrate that D2 receptor mutation preferentially increases the amplitude of the inner retinal light responses evoked by high-intensity light measured as oscillatory potentials in adult mice. During postnatal development, all three major components of electroretinograms, i.e. a-waves, b-waves, and oscillatory potentials, increase with age. Comparatively, D2 receptor mutation preferentially reduces the age-dependent increase in b-waves evoked by low-intensity light. Light deprivation from birth reduces b-wave amplitudes and completely abolishes the increased amplitude of oscillatory potentials of D2 receptor mutants. Taken together, these results demonstrate that D2 receptors play an important role in the activity-dependent functional development of the mouse retina.
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