ArticleAngewandte Chemie (International ed. in English)2015
Biocompatible infinite-coordination-polymer nanoparticle-nucleic-acid conjugates for antisense gene regulation.
Article in Angewandte Chemie (International ed. in English), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- A first-in-human phase 0 clinical study of RNA interference-based spherical nucleic acids in patients with recurrent glioblastoma.Science translational medicine · 2021Trial
- Enhancing Endosomal Escape and Gene Regulation Activity for Spherical Nucleic Acids.Small (Weinheim an der Bergstrasse, Germany) · 2024Article
- Original Synthesis of a Nucleolipid for Preparation of Vesicular Spherical Nucleic Acids.Nanomaterials (Basel, Switzerland) · 2022Article
- Nucleic acid-based supramolecular structures: vesicular spherical nucleic acids from a non-phospholipid nucleolipid.Nanoscale advances · 2022Article
- Spherical nucleic acids: Organized nucleotide aggregates as versatile nanomedicine.Aggregate (Hoboken, N.J.) · 2022Article
- Spherical Nucleic Acids: Integrating Nanotechnology Concepts into General Chemistry Curricula.Journal of chemical education · 2021Article
- Attenuation of Abnormal Scarring Using Spherical Nucleic Acids Targeting Transforming Growth Factor Beta 1.ACS applied bio materials · 2020Article
- Design of Targeted Nanostructured Coordination Polymers (NCPs) for Cancer Therapy.Molecules (Basel, Switzerland) · 2020Review
- Tumor cell lysate-loaded immunostimulatory spherical nucleic acids as therapeutics for triple-negative breast cancer.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Surface-Initiated Atom Transfer Polymerized Anionic Corona on Gold Nanoparticles for Anti-Cancer Therapy.Pharmaceutics · 2020Article
- Impact of Sequence Specificity of Spherical Nucleic Acids on Macrophage Activation in Vitro and in Vivo.Molecular pharmaceutics · 2019Article
- FeJournal of the American Chemical Society · 2019Article
- Dual Toll-Like Receptor Targeting Liposomal Spherical Nucleic Acids.Bioconjugate chemistry · 2019Article
- A multifunctional DNA nano-scorpion for highly efficient targeted delivery of mRNA therapeutics.Scientific reports · 2018Article
- Molecular spherical nucleic acids.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Enhancing the Stability and Immunomodulatory Activity of Liposomal Spherical Nucleic Acids through Lipid-Tail DNA Modifications.Small (Weinheim an der Bergstrasse, Germany) · 2018Article
- Liposomal Spherical Nucleic Acids for Regulating Long Noncoding RNAs in the Nucleus.Small (Weinheim an der Bergstrasse, Germany) · 2017Article
- A DNA dual lock-and-key strategy for cell-subtype-specific siRNA delivery.Nature communications · 2016Article
- Stimulus-responsive light-harvesting complexes based on the pillararene-induced co-assembly of β-carotene and chlorophyll.Nature communications · 2016Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Herein, we report the synthesis of DNA-functionalized infinite-coordination-polymer (ICP) nanoparticles as biocompatible gene-regulation agents. ICP nanoparticles were synthesized from ferric nitrate and a ditopic 3-hydroxy-4-pyridinone (HOPO) ligand bearing a pendant azide. Addition of Fe(III) to a solution of the ligand produced nanoparticles, which were colloidally unstable in the presence of salts. Conjugation of DNA to the Fe(III)-HOPO ICP particles by copper-free click chemistry afforded colloidally stable nucleic-acid nanoconstructs. The DNA-ICP particles, when cross-linked through sequence-specific hybridization, exhibited narrow, highly cooperative melting transitions consistent with dense DNA surface loading. The ability of the DNA-ICP particles to enter cells and alter protein expression was also evaluated. Our results indicate that these novel particles carry nucleic acids into mammalian cells without the need for transfection agents and are capable of efficient gene knockdown.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.