ArticlePloS one2014
Coincident pre-diabetes is associated with dysregulated cytokine responses in pulmonary tuberculosis.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Immune dysregulation in tuberculosis-diabetes comorbidity: mechanistic and translational insights.Frontiers in immunology · 2026Pooled it
- Persistent Hyperglycaemia and Transient Dysglycaemia in Tuberculosis: Evaluating the Bidirectional Interaction With Type-2 Diabetes Mellitus and Clinical Outcomes.Tropical medicine & international health : TM & IH · 2026Article
- Assessing the effects of diabetes mellitus on the monocyte-to-lymphocyte ratio and the QuantiFERON-TB gold plus assays for tuberculosis treatment monitoring: a prospective cohort study.Frontiers in immunology · 2024Article
- Cytokine and chemokine profiles in pulmonary tuberculosis with pre-diabetes.Frontiers in immunology · 2024Article
- Failure to decrease HbA1c levels following TB treatment is associated with elevated Th1/Th17 CD4+ responses.Frontiers in immunology · 2023Observational
- The cause-effect relation of tuberculosis on incidence of diabetes mellitus.Frontiers in cellular and infection microbiology · 2023Review
- Tuberculosis and diabetes mellitus: Relating immune impact of co-morbidity with challenges in disease management in high burden countries.Journal of clinical tuberculosis and other mycobacterial diseases · 2022Article
- Multi-Dimensionality Immunophenotyping Analyses of MAIT Cells Expressing Th1/Th17 Cytokines and Cytotoxic Markers in Latent Tuberculosis Diabetes Comorbidity.Pathogens (Basel, Switzerland) · 2022Article
- Respiratory Tract Infections in Diabetes - Lessons From Tuberculosis and Influenza to Guide Understanding of COVID-19 Severity.Frontiers in endocrinology · 2022Review
- Impact of Intermediate Hyperglycemia and Diabetes on Immune Dysfunction in Tuberculosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Pre-Diabetes Increases Tuberculosis Disease Severity, While High Body Fat Without Impaired Glucose Tolerance Is Protective.Frontiers in cellular and infection microbiology · 2021Article
- Slow radiological improvement and persistent low-grade inflammation after chemotherapy in tuberculosis patients with type 2 diabetes.BMC infectious diseases · 2020Observational
- Lipid mediators of inflammation and Resolution in individuals with tuberculosis and tuberculosis-Diabetes.Prostaglandins & other lipid mediators · 2020Article
- The gut microbiome in tuberculosis susceptibility and treatment response: guilty or not guilty?Cellular and molecular life sciences : CMLS · 2020Review
- Evidence for a More Disrupted Immune-Endocrine Relation and Cortisol Immunologic Influences in the Context of Tuberculosis and Type 2 Diabetes Comorbidity.Frontiers in endocrinology · 2020Article
- Changes in Host Response toFrontiers in cellular and infection microbiology · 2019Review
- Building capacity for advances in tuberculosis research; proceedings of the third RePORT international meeting.Tuberculosis (Edinburgh, Scotland) · 2018Article
- Patients with type 1 diabetes mellitus have impaired IL-1β production in response to Mycobacterium tuberculosis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Article
- Influence of diabetes mellitus on immunity to human tuberculosis.Immunology · 2017Review
- Review
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundCytokines play an important role in the pathogenesis of pulmonary tuberculosis (PTB)--Type 2 diabetes mellitus co-morbidity. However, the cytokine interactions that characterize PTB coincident with pre-diabetes (PDM) are not known.
methodsTo identify the influence of coincident PDM on cytokine levels in PTB, we examined circulating levels of a panel of cytokines in the plasma of individuals with TB-PDM and compared them with those without PDM (TB-NDM).
resultsTB-PDM is characterized by elevated circulating levels of Type 1 (IFNγ, TNFα and IL-2), Type 17 (IL-17A and IL-17F) and other pro-inflammatory (IL-1β, IFNβ and GM-CSF) cytokines. TB-PDM is also characterized by increased systemic levels of Type 2 (IL-5) and regulatory (IL-10 and TGFβ) cytokines. Moreover, TB antigen stimulated whole blood also showed increased levels of pro-inflammatory (IFNγ, TNFα and IL-1β) cytokines as well. However, the cytokines did not exhibit any significant correlation with HbA1C levels or with bacterial burdens.
conclusionOur data reveal that pre-diabetes in PTB individuals is characterized by heightened cytokine responsiveness, indicating that a balanced pro and anti - inflammatory cytokine milieu is a feature of pre-diabetes--TB co-morbidity.
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Registered trials
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