Evidence map›Paper›PMID 25393631›Full record

ArticleEpidemiology (Cambridge, Mass.)2015

Chronic kidney disease and risk of renal cell carcinoma: differences by race.

Jonathan N Hofmann, Douglas A Corley, Wei K Zhao, Joanne S Colt, Brian Shuch, Wong-Ho Chow, Mark P Purdue

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epidemiology (Cambridge, Mass.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.

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  13. Associations of Renal Cell Carcinoma Subtype with Patient Demographics, Comorbidities, and Neighborhood Socioeconomic Status in the California Population.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Jonathan N HofmannFrom the aOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD; bDivision of Research, Kaiser Permanente Northern California, Oakland, CA; cDepartment of Urology, Yale School of Medicine, New Haven, CT; dDepartment of Epidemiology, The University of Texas, Houston, TX; and eOntario Institute for Cancer Research, Toronto, ON, Canada.
Douglas A Corley
Wei K Zhao
Joanne S Colt
Brian Shuch
Wong-Ho Chow
Mark P Purdue
Kaiser Permanente · USNational Cancer Institute · USOntario Institute for Cancer Research · CAThe University of Texas Health Science Center at Houston · USYale University · US

Funding

Cancer Risk in Human PopulationsZIACP010136 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI PURDUE, MARK · 2009 to 2025
$36.7M
Occupational and Environmental Determinants of Cancer among Women and MinoritiesZIACP010123 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI HOFMANN, JONATHAN · 2009 to 2025
$8.3M
Intramural NIH HHS ZIA CP010123
6 · The paper itself

Abstract

backgroundThe incidence of renal cell carcinoma in the United States differs by race/ethnicity. To better understand these disparities, we conducted a nested case-control study investigating renal cell carcinoma risk factors across racial/ethnic groups within the Kaiser Permanente Northern California health care network.

methodsOur study included 3136 renal cell carcinoma cases (2152 whites, 293 blacks, 425 Hispanics, and 255 Asians) diagnosed between 1998 and 2008 and 31031 individually matched controls (21478 whites, 2836 blacks, 4147 Hispanics, and 2484 Asians). Risk of renal cell carcinoma was assessed in relation to smoking status, body mass index (BMI), hypertension, and chronic kidney disease. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) using conditional logistic regression, and population attributable risk (PAR) to estimate by race the proportion of cases attributable to hypertension and chronic kidney disease.

resultsThe association between chronic kidney disease and renal cell carcinoma differed markedly by race (Pinteraction < 0.001), with associations observed among blacks (OR = 10.4 [95% CI = 6.0-17.9]), Asians (5.1 [2.2-11.7]), and Hispanics (2.3 [1.1-4.6]) but not whites (1.1 [0.6-1.9]). Hypertension, high BMI, and smoking were associated with renal cell carcinoma, but findings generally did not differ by race. Relative to other racial/ethnic groups, blacks had the highest proportion of renal cell carcinoma incidence attributable to hypertension and chronic kidney disease (combined, PAR = 37%; hypertension only, PAR = 27%; chronic kidney disease, PAR = 10%).

conclusionsOur findings suggest that hypertension and chronic kidney disease likely have contributed to the observed excess in renal cell carcinoma incidence among blacks compared with whites.

Indexed as

AdolescentAdultAgedAged, 80 and overAsianBlack or African AmericanBody Mass IndexCarcinoma, Renal CellCase-Control StudiesEthnicityFemaleHispanic or LatinoHumansHypertensionKidney NeoplasmsLogistic Models

Identifiers

PMID25393631
PMCPMC4422505
OpenAlexW2325289081

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.