ArticlePloS one2014
Genetic control of startle behavior in medaka fish.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Structured spontaneous activity through delta oscillation-based discrete states in the medaka telencephalon.Scientific reports · 2026Article
- Linked genetic loci and genotype-dependent temperature effects shape craniofacial morphology in medaka.G3 (Bethesda, Md.) · 2026Article
- Measurement and classification of bold-shy behaviours in medaka fish.Bioinformatics (Oxford, England) · 2025Article
- Evolution of Size-Fecundity Relationship in Medaka Fish From Different Latitudes.Molecular ecology · 2024Article
- Variation in responses to photoperiods and temperatures in Japanese medaka from different latitudes.Zoological letters · 2023Article
- Conserved and diverged asymmetric gene expression in the brain of teleosts.Frontiers in cell and developmental biology · 2022Article
- Interspecies Behavioral Variability of Medaka Fish Assessed by Comparative Phenomics.International journal of molecular sciences · 2021Article
- Genetic analysis of body weight in wild populations of medaka fish from different latitudes.PloS one · 2020Article
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Authors and funding
10 authors at 4 institutions in 1 country.
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Abstract
Genetic polymorphisms are thought to generate intraspecific behavioral diversities, both within and among populations. The mechanisms underlying genetic control of behavioral properties, however, remain unclear in wild-type vertebrates, including humans. To explore this issue, we used diverse inbred strains of medaka fish (Oryzias latipes) established from the same and different local populations. Medaka exhibit a startle response to a visual stimulus (extinction of illumination) by rapidly bending their bodies (C-start) 20-ms after the stimulus presentation. We measured the rates of the response to repeated stimuli (1-s interval, 40 times) among four inbred strains, HNI-I, HNI-II, HO5, and Hd-rR-II1, and quantified two properties of the startle response: sensitivity (response rate to the first stimulus) and attenuation of the response probability with repeated stimulus presentation. Among the four strains, the greatest differences in these properties were detected between HNI-II and Hd-rR-II1. HNI-II exhibited high sensitivity (approximately 80%) and no attenuation, while Hd-rR-II1 exhibited low sensitivity (approximately 50%) and almost complete attenuation after only five stimulus presentations. Our findings suggested behavioral diversity of the startle response within a local population as well as among different populations. Linkage analysis with F2 progeny between HNI-II and Hd-rR-II1 detected quantitative trait loci (QTL) highly related to attenuation, but not to sensitivity, with a maximum logarithm of odds score of 11.82 on linkage group 16. The three genotypes (homozygous for HNI-II and Hd-rR-II1 alleles, and heterozygous) at the marker nearest the QTL correlated with attenuation. Our findings are the first to suggest that a single genomic region might be sufficient to generate individual differences in startle behavior between wild-type strains. Further identification of genetic polymorphisms that define the behavioral trait will contribute to our understanding of the neural mechanisms underlying behavioral diversity, allowing us to investigate the adaptive significance of intraspecific behavioral polymorphisms of the startle response.
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