ArticleInternational journal of molecular sciences2014
Berteroin present in cruciferous vegetables exerts potent anti-inflammatory properties in murine macrophages and mouse skin.
Article in International journal of molecular sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Immunomodulatory Effects and Regulatory Mechanisms of (Journal of agricultural and food chemistry · 2024Article
- Article
- The effects of berteroin on inflammatory mediators and antioxidant enzymes expression in human periodontal ligament cells.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- 5-methylthiopentyl Isothiocyanate, a Sulforaphane Analogue, Inhibits Pro-inflammatory Cytokines by Regulating LPS/ATP-mediated NLRP3 Inflammasome Activation.Current pharmaceutical biotechnology · 2024Article
- Developing multifunctional crops by engineering Brassicaceae glucosinolate pathways.Plant communications · 2023Review
- 4-phenylpyridine suppresses UVB-induced skin inflammation by targeting c-Src in vitro and in vivo.Journal of cellular and molecular medicine · 2022Article
- Anti-Inflammatory Functions of Methanol Extract fromPlants (Basel, Switzerland) · 2022Article
- Chemosensory approach supported-analysis of wintering radishes produced in Jeju island by different processing methods.Food science and biotechnology · 2021Article
- Article
- Kale supplementation during high fat feeding improves metabolic health in a mouse model of obesity and insulin resistance.PloS one · 2021Article
- Article
- Diet phytochemicals and cutaneous carcinoma chemoprevention: A review.Pharmacological research · 2017Review
- Effects of MeJA on Arabidopsis metabolome under endogenous JA deficiency.Scientific reports · 2016Article
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8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Berteroin (5-methylthiopentyl isothiocyanate) is a sulforaphane analog present in cruciferous vegetables, including Chinese cabbage, rucola salad leaves, and mustard oil. We examined whether berteroin exerts anti-inflammatory activities using lipopolysaccharide (LPS)-stimulated Raw 264.7 macrophages and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse skin inflammation models. Berteroin decreased LPS-induced release of inflammatory mediators and pro-inflammatory cytokines in Raw 264.7 macrophages. Berteroin inhibited LPS-induced degradation of inhibitor of κBα (IκBα) and nuclear factor-κB p65 translocation to the nucleus and DNA binding activity. Furthermore, berteroin suppressed degradation of IL-1 receptor-associated kinase and phosphorylation of transforming growth factor β activated kinase-1. Berteroin also inhibited LPS-induced phosphorylation of p38 MAPK, ERK1/2, and AKT. In the mouse ear, berteroin effectively suppressed TPA-induced edema formation and down-regulated iNOS and COX-2 expression as well as phosphorylation of AKT and ERK1/2. These results demonstrate that berteroin exhibits potent anti-inflammatory properties and suggest that berteroin can be developed as a skin anti-inflammatory agent.
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