Evidence map›Paper›PMID 25393381›Full record

ArticleMacromolecular bioscience2015

Thermoresponsive self-assembly of nanostructures from a collagen-like peptide-containing diblock copolymer.

Tianzhi Luo, Lirong He, Patrick Theato, Kristi L Kiick

Open access · greenAbstract read
In one paragraph

Article in Macromolecular bioscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
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  12. Responsive Hybrid (Poly)peptide-Polymer Conjugates.Journal of materials chemistry. B · 2017
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Tianzhi LuoDepartment of Materials Science and Engineering, University of Delaware, Newark, DE, 19716, USA.
Lirong He
Patrick Theato
Kristi L Kiick
Universität Hamburg · DEBiotechnology Institute · USUniversity of Delaware · US

Funding

COBRE on Membrane Protein Production and CharacterizationP30GM103519 · NIGMS · UNIVERSITY OF DELAWARE · PI LENHOFF, ABRAHAM M · 2012 to 2014
$3.3M
NIGMS NIH HHS P30 GM103519
6 · The paper itself

Abstract

Temperature-triggered formation of nanostructures with distinct biological activity offers opportunities in selective modification of matrices and in drug delivery. Toward these ends, diblock polymers comprising poly(diethylene glycol methyl ether methacrylate) (PDEGMEMA) conjugated to a triple helix-forming collagen-like peptide were produced. Triggered by the collapse of the thermoresponsive domain above its LCST, the conjugate undergoes a reversible transition in aqueous solution to form well-defined nanovesicles with diameters of approximately 100 nm, with a transition temperature of 37 °C. The incorporation of CLP domains in these nanostructures may offer opportunities for the selective targeting of collagen-containing matrices.

Indexed as

Hot TemperatureAcrylatesChromatography, GelCircular DichroismCollagenDrug Delivery SystemsMacromolecular SubstancesMagnetic Resonance SpectroscopyMicroscopy, Electron, TransmissionNanomedicineNanostructuresPeptidesPolyethylene GlycolsPolymersTransport VesiclesAcrylatesCollagenMacromolecular SubstancesPeptidesPolyethylene GlycolsPolymerscollagen-like peptidedrug deliveryself-assemblythermoresponsivevesicle

Identifiers

PMID25393381
PMCPMC4562312
OpenAlexW1515459474

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.