Trial reportPloS one2014
Methadone induction in primary care for opioid dependence: a pragmatic randomized trial (ANRS Methaville).
Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00657397 (Initialization of Methadone in Primary Care; a Randomized Intervention Research for Preventing HCV Transmission Practices. ANRS Methaville), which is not on this map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Initialization of Methadone in Primary Care; a Randomized Intervention Research for Preventing HCV Transmission Practices. ANRS Methaville
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Opioid agonist therapy for opioid use disorder in primary versus specialty care.The Cochrane database of systematic reviews · 2025Pooled it
- Supervised dosing with a long-acting opioid medication in the management of opioid dependence.The Cochrane database of systematic reviews · 2017Pooled it
- Primary care models for treating opioid use disorders: What actually works? A systematic review.PloS one · 2017Pooled it
- Integrating Methadone Services Into Primary Care in Ukraine: Two-Year Outcomes From a Randomized Trial.Annals of internal medicine · 2026Trial
- Re-engineering methadone-Cost-effectiveness analysis of a patient-centered approach to methadone treatment.Journal of substance abuse treatment · 2018Trial
- Pain in methadone patients: Time to address undertreatment and suicide risk (ANRS-Methaville trial).PloS one · 2017Trial
- Phase synchronization alterations of EEG oscillations during emotional video processing in depression and anxiety: a transdiagnostic study.European archives of psychiatry and clinical neuroscience · 2026Article
- Retention Challenges in Opioid Use Disorder Treatment: The Role of Comorbid Psychological Conditions.The western journal of emergency medicine · 2025Article
- Challenges of methadone maintenance treatment decentralisation from Vietnamese primary care providers' perspectives.Drug and alcohol review · 2023Article
- Adherence to opioid agonist therapy predicts uptake of direct-acting antivirals in people who use drugs: results from the French national healthcare database (the ANRS FANTASIO study).Harm reduction journal · 2022Article
- Office-Based Methadone Treatment for Opioid Use Disorder and Pharmacy Dispensing: A Scoping Review.The American journal of psychiatry · 2021Article
- Prospective Study on Factors Associated with Referral of Patients with Opioid Maintenance Therapy from Specialized Addictive Disorders Centers to Primary Care.International journal of environmental research and public health · 2021Observational
- Treating opioid use disorder in primary care.Canadian family physician Medecin de famille canadien · 2019Article
- The OPTIMA study, buprenorphine/naloxone and methadone models of care for the treatment of prescription opioid use disorder: Study design and rationale.Contemporary clinical trials · 2018Article
- Willingness to receive intravenous buprenorphine treatment in opioid-dependent people refractory to oral opioid maintenance treatment: results from a community-based survey in France.Substance abuse treatment, prevention, and policy · 2017Article
- Intravenous heroin use in Haiphong, Vietnam: Need for comprehensive care including methamphetamine use-related interventions.Drug and alcohol dependence · 2017Article
- A longitudinal and case-control study of dropout among drug users in methadone maintenance treatment in Haiphong, Vietnam.Harm reduction journal · 2017Article
- Primary healthcare-based integrated care with opioid agonist treatment: First experience from Ukraine.Drug and alcohol dependence · 2017Observational
- A prospective, longitudinal study of sleep disturbance and comorbidity in opiate dependence (the ANRS Methaville study).Psychopharmacology · 2016Article
- The impact of low-threshold methadone maintenance treatment on mortality in a Canadian setting.Drug and alcohol dependence · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveMethadone coverage is poor in many countries due in part to methadone induction being possible only in specialized care (SC). This multicenter pragmatic trial compared the effectiveness of methadone treatment between two induction models: primary care (PC) and SC.
methodsIn this study, registered at ClinicalTrials.Gov (NCT00657397), opioid-dependent individuals not on methadone treatment for at least one month or receiving buprenorphine but needing to switch were randomly assigned to start methadone in PC (N = 155) or in SC (N = 66) in 10 sites in France. Visits were scheduled at months M0, M3, M6 and M12. The primary outcome was self-reported abstinence from street-opioids at 12 months (M12) (with an underlying 15% non-inferiority hypothesis for PC). Secondary outcomes were abstinence during follow-up, engagement in treatment (i.e. completing the induction period), retention and satisfaction with the explanations provided by the physician. Primary analysis used intention to treat (ITT). Mixed models and the log-rank test were used to assess the arm effect (PC vs. SC) on the course of abstinence and retention, respectively.
resultsIn the ITT analysis (n = 155 in PC, 66 in SC), which compared the proportions of street-opioid abstinent participants, 85/155 (55%) and 22/66 (33%) of the participants were classified as street-opioid abstinent at M12 in PC and SC, respectively. This ITT analysis showed the non-inferiority of PC (21.5 [7.7; 35.3]). Engagement in treatment and satisfaction with the explanations provided by the physician were significantly higher in PC than SC. Retention in methadone and abstinence during follow-up were comparable in both arms (p = 0.47, p = 0.39, respectively).
conclusionsUnder appropriate conditions, methadone induction in primary care is feasible and acceptable to both physicians and patients. It is as effective as induction in specialized care in reducing street-opioid use and ensuring engagement and retention in treatment for opioid dependence.
trial registrationNumber Eudract 2008-001338-28; ClinicalTrials.gov: NCT00657397; International Standard Randomized Controlled Trial Number Register ISRCTN31125511.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.