Trial reportPloS one2014
Delineation of early and later adult onset depression by diffusion tensor imaging.
Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00703742 (A Neuroimaging and Epigenetic Investigation of Antidepressants in Depression), which is not on this map. Cited by 30 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Neuroimaging and Epigenetic Investigation of Antidepressants in Depression
Who cites it
30 citing papers in PubMed, 4 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Brain-based Sex Differences in Depression: A Systematic Review of Neuroimaging Studies.Brain imaging and behavior · 2023Pooled it
- Unraveling the mystery of white matter in depression: A translational perspective on recent advances.Brain and behavior · 2022Pooled it
- Data-driven biological subtypes of depression: systematic review of biological approaches to depression subtyping.Molecular psychiatry · 2019Pooled it
- Microstructural brain abnormalities in medication-free patients with major depressive disorder: a systematic review and meta-analysis of diffusion tensor imaging.Journal of psychiatry & neuroscience : JPN · 2017Pooled it
- Multimodal fusion of structural and functional brain imaging in depression using linked independent component analysis.Human brain mapping · 2020Trial
- Network-level disconnectivity tracks poststroke depressive symptom improvement.Psychiatry and clinical neurosciences · 2026Observational
- Multimodal Representation Learning for Parsing Biological Heterogeneity in Psychiatric Neuroimaging.Biological psychiatry · 2026Review
- The Cortico-Cortical and Subcortical Circuits of the Human Brain Language Centers Including the Dual Limbic and Language Functioning Fiber Tracts.Brain sciences · 2026Review
- Demyelination and Cognitive Performance in Long COVID Patients with Insomnia and/or Depression.International journal of molecular sciences · 2025Article
- Oligodendrocyte lineage cells dysfunction in depression: early life stress, adolescent vulnerability and the emerging role of lipid metabolism.Translational psychiatry · 2025Review
- Integrating brain imaging features and genomic profiles for the subtyping of major depression.Psychological medicine · 2025Article
- Demyelination in Patients with POST-COVID Depression.Journal of clinical medicine · 2024Article
- Challenges in Identifying Individualized Brain Biomarkers of Late Life Depression.Advances in geriatric medicine and research · 2023Article
- Identification of transdiagnostic psychiatric disorder subtypes using unsupervised learning.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Replicable association between human cytomegalovirus infection and reduced white matter fractional anisotropy in major depressive disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Diffusion Tensor Imaging Group Analysis Using Tract Profiling and Directional Statistics.Frontiers in neuroscience · 2021Article
- Assessment of Disrupted Brain Structural Connectome in Depressive Patients With Suicidal Ideation Using Generalized Q-Sampling MRI.Frontiers in human neuroscience · 2021Article
- Targeted sequencing of the BDNF gene in young Chinese Han people with major depressive disorder.Molecular genetics & genomic medicine · 2020Article
- White matter microstructure relates to lassitude but not diagnosis in adolescents with depression.Brain imaging and behavior · 2020Article
- White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group.Molecular psychiatry · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDue to a lack of evidence, there is no consistent age of onset to define early onset (EO) versus later onset (LO) major depressive disorder (MDD). Fractional anisotropy (FA), derived from diffusion tensor imaging (DTI), has been widely used to study neuropsychiatric disorders by providing information about the brain circuitry, abnormalities of which might facilitate the delineation of EO versus LO MDD.
methodIn this study, 61 pairs of untreated, non-elderly, first-episode MDD patients and healthy controls (HCs) aged 18-45 years old received DTI scans. The voxel-based analysis method (VBM), classification analysis, using the Statistical Package for the Social Sciences (SPSS), and regression analyses were used to determine abnormal FA clusters and their correlations with age of onset and clinical symptoms.
resultsClassification analysis suggested in the best model that there were two subgroups of MDD patients, delineated by an age of onset of 30 years old, by which MDD patients could be divided into EO (18-29 years old) and LO (30-45 years old) groups. LO MDD was characterized by decreased FA, especially in the white matter (WM) of the fronto-occipital fasciculus and posterior limb of internal capsule, with a negative correlation with the severity of depressive symptoms; in marked contrast, EO MDD showed increased FA, especially in the WM of the corpus callosum, corticospinal midbrain and inferior fronto-occipital fasciculus, while FA of the WM near the midbrain had a positive correlation with the severity of depressive symptoms.
conclusionSpecific abnormalities of the brain circuitry in EO vs. LO MDD were delineated by an age of onset of 30 years old, as demonstrated by distinct abnormal FA clusters with opposite correlations with clinical symptoms. This DTI study supported the evidence of an exact age for the delineation of MDD, which could have broad multidisciplinary importance.
trial registrationClinicalTrials.gov NCT00703742.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.