Evidence map›Paper›PMID 25393240›Full record

ArticlePloS one2014

The great roundleaf bat (Hipposideros armiger) as a good model for cold-induced browning of intra-abdominal white adipose tissue.

Yao Wang, Tengteng Zhu, Shanshan Ke, Na Fang, David M Irwin, Ming Lei, Junpeng Zhang, Huizhen Shi, Shuyi Zhang, Zhe Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Yao WangInstitute of Molecular Ecology and Evolution, East China Normal University, Shanghai, China.
Tengteng ZhuInstitute of Molecular Ecology and Evolution, East China Normal University, Shanghai, China.
Shanshan KeInstitute of Molecular Ecology and Evolution, East China Normal University, Shanghai, China.
Na FangInstitute of Molecular Ecology and Evolution, East China Normal University, Shanghai, China.
David M IrwinDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.
Ming LeiInstitute of Molecular Ecology and Evolution, East China Normal University, Shanghai, China.
Junpeng ZhangInstitute of Molecular Ecology and Evolution, East China Normal University, Shanghai, China.
Huizhen ShiInstitute of Molecular Ecology and Evolution, East China Normal University, Shanghai, China.
Shuyi ZhangInstitute of Molecular Ecology and Evolution, East China Normal University, Shanghai, China.
Zhe WangInstitute of Molecular Ecology and Evolution, East China Normal University, Shanghai, China.
East China Normal University · CNUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInducing beige fat from white adipose tissue (WAT) is considered to be a shortcut to weight loss and increasingly becoming a key area in research into treatments for obesity and related diseases. However, currently, animal models of beige fat are restricted to rodents, where subcutaneous adipose tissue (sWAT, benign WAT) is more liable to develop into the beige fat under specific activators than the intra-abdominal adipose tissue (aWAT, malignant WAT) that is the major source of obesity related diseases in humans.

methodsHere we induced beige fat by cold exposure in two species of bats, the great roundleaf bat (Hipposideros armiger) and the rickett's big-footed bat (Myotis ricketti), and compared the molecular and morphological changes with those seen in the mouse. Expression of thermogenic genes (Ucp1 and Pgc1a) was measured by RT-qPCR and adipocyte morphology examined by HE staining at three adipose locations, sWAT, aWAT and iBAT (interscapular brown adipose tissue).

resultsExpression of Ucp1 and Pgc1a was significantly upregulated, by 729 and 23 fold, respectively, in aWAT of the great roundleaf bat after exposure to 10°C for 7 days. Adipocyte diameters of WATs became significantly reduced and the white adipocytes became brown-like in morphology. In mice, similar changes were found in the sWAT, but much lower amounts of changes in aWAT were seen. Interestingly, the rickett's big-footed bat did not show such a tendency in beige fat.

conclusionsThe great roundleaf bat is potentially a good animal model for human aWAT browning research. Combined with rodent models, this model should be helpful for finding therapies for reducing harmful aWAT in humans.

Indexed as

Adaptation, PhysiologicalAdipose Tissue, BrownAdipose Tissue, WhiteAnimalsChiropteraCold TemperatureGene Expression RegulationIntra-Abdominal FatIon ChannelsMiceMitochondrial ProteinsModels, AnimalSubcutaneous FatThermogenesisUncoupling Protein 1Weight LossIon ChannelsMitochondrial ProteinsUCP1 protein, humanUcp1 protein, mouseUncoupling Protein 1

Identifiers

PMID25393240
PMCPMC4231071
OpenAlexW2049218919

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.