ArticlePLoS genetics2014
The talin head domain reinforces integrin-mediated adhesion by promoting adhesion complex stability and clustering.
Article in PLoS genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- The actin binding sites of talin have both distinct and complementary roles in cell-ECM adhesion.PLoS genetics · 2024Article
- Force-dependent focal adhesion assembly and disassembly: A computational study.PLoS computational biology · 2023Article
- Talin variant P229S compromises integrin activation and associates with multifaceted clinical symptoms.Human molecular genetics · 2022Article
- The role of integrins in inflammation and angiogenesis.Pediatric research · 2021Review
- Cancer associated talin point mutations disorganise cell adhesion and migration.Scientific reports · 2021Article
- Recent Advances and Prospects in the Research of Nascent Adhesions.Frontiers in physiology · 2020Review
- Force-Induced Calpain Cleavage of Talin Is Critical for Growth, Adhesion Development, and Rigidity Sensing.Nano letters · 2017Article
- Substrate properties modulate cell membrane roughness by way of actin filaments.Scientific reports · 2017Article
- Structural and Functional Analysis of a Talin Triple-Domain Module Suggests an Alternative Talin Autoinhibitory Configuration.Structure (London, England : 1993) · 2016Article
- Talin1 is required for cardiac Z-disk stabilization and endothelial integrity in zebrafish.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- In vivo quantitative analysis of Talin turnover in response to force.Molecular biology of the cell · 2015Article
- Regulation of integrin-mediated adhesions.Current opinion in cell biology · 2015Review
- Alternative mechanisms for talin to mediate integrin function.Current biology : CB · 2015Article
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Authors and funding
8 authors at 4 institutions in 4 countries.
Funding
Abstract
Talin serves an essential function during integrin-mediated adhesion in linking integrins to actin via the intracellular adhesion complex. In addition, the N-terminal head domain of talin regulates the affinity of integrins for their ECM-ligands, a process known as inside-out activation. We previously showed that in Drosophila, mutating the integrin binding site in the talin head domain resulted in weakened adhesion to the ECM. Intriguingly, subsequent studies showed that canonical inside-out activation of integrin might not take place in flies. Consistent with this, a mutation in talin that specifically blocks its ability to activate mammalian integrins does not significantly impinge on talin function during fly development. Here, we describe results suggesting that the talin head domain reinforces and stabilizes the integrin adhesion complex by promoting integrin clustering distinct from its ability to support inside-out activation. Specifically, we show that an allele of talin containing a mutation that disrupts intramolecular interactions within the talin head attenuates the assembly and reinforcement of the integrin adhesion complex. Importantly, we provide evidence that this mutation blocks integrin clustering in vivo. We propose that the talin head domain is essential for regulating integrin avidity in Drosophila and that this is crucial for integrin-mediated adhesion during animal development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.