ArticlePloS one2014
Serological investigation of food specific immunoglobulin G antibodies in patients with inflammatory bowel diseases.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Predefined Diets in Patients with Inflammatory Bowel Disease: Systematic Review and Meta-Analysis.Nutrients · 2020Pooled it
- The Influence of Reducing Diets on Changes in Thyroid Parameters in Women Suffering from Obesity and Hashimoto's Disease.Nutrients · 2021Trial
- Medication Use and Guideline Adherence in Inflammatory Bowel Disease Management: A Retrospective Study from a Tertiary Care Hospital in Pakistan (2019-2024).International journal of general medicine · 2026Article
- IgG4 unveiled: navigating the interplay with Crohn's disease - from immunology insights to machine learning.Annals of medicine and surgery (2012) · 2025Review
- Prevalence of Anti-Pathogens (Basel, Switzerland) · 2025Article
- IgA Antibodies to Bovine Serum Albumin in Adult Patients with Celiac Disease.International journal of molecular sciences · 2025Article
- Food Intolerance and Allergy: Do They Have an Etiological Role in Idiopathic Granulomatous Mastitis?Journal of clinical medicine · 2025Article
- Association between allergic diseases and mucosal healing in ulcerative colitis.Scientific reports · 2025Article
- Adverse Food Reactions in Inflammatory Bowel Disease: State of the Art and Future Perspectives.Nutrients · 2024Review
- Serum food specific IgG antibodies are associated with small bowel inflammation in patients with Crohn's disease.European journal of clinical nutrition · 2024Observational
- Mediation role of body mass index in the relationship between food-specific serum immunoglobulin G reactivity and colorectal adenomas in a Chinese population: a cross-sectional study.Therapeutic advances in gastroenterology · 2024Article
- Akkermansia muciniphila exacerbates food allergy in fibre-deprived mice.Nature microbiology · 2023Article
- Small bowel stomas are associated with higher risk of circulating food-specific-IgG than patients with organic gastrointestinal conditions and colostomies.BMJ open gastroenterology · 2022Article
- Associations between food-specific IgG and health outcomes in an asymptomatic physical examination cohort.Nutrition & metabolism · 2022Article
- Association betweenWorld journal of clinical cases · 2021Article
- Inflammatory Bowel Disease: Are Symptoms and Diet Linked?Nutrients · 2020Article
- The Successful Management Of Ulcerative Colitis With A Nutritional Intervention: A Case Report.Integrative medicine (Encinitas, Calif.) · 2019Article
- Fabrication of Microarrays for the Analysis of Serological Antibody Isotypes against Food Antigens.Sensors (Basel, Switzerland) · 2019Article
- Serological investigation of IgG and IgE antibodies against food antigens in patients with inflammatory bowel disease.World journal of clinical cases · 2019Article
- Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveDietary factors have been indicated to influence the pathogenesis and nature course of inflammatory bowel diseases (IBD) with their wide variances. The aim of the study was to assess the prevalence and clinical significance of 14 serum food specific immunoglobulin G (sIgG) antibodies in patients with IBD.
methodsThis retrospective study comprised a total of 112 patients with IBD, including 79 with Crohn's disease (CD) and 33 with ulcerative colitis (UC). Medical records, clinical data and laboratory results were collected for analysis. Serum IgG antibodies against 14 unique food allergens were detected by semi-quantitative enzyme linked immunosorbent assay (ELISA).
resultsFood sIgG antibodies were detected in 75.9% (60/79) of CD patients, 63.6% (21/33) of UC patients and 33.1% (88/266) of healthy controls (HC). IBD patients showed the significantly higher antibodies prevalence than healthy controls (CD vs. HC, P = 0.000; UC vs. HC, P = 0.001). However no marked difference was observed between CD and UC groups (P = 0.184). More subjects were found with sensitivity to multiple antigens (≥ 3) in IBD than in HC group (33.9% vs.0.8%, P = 0.000). Egg was the most prevalent food allergen. There was a remarkable difference in the levels of general serum IgM (P = 0.045) and IgG (P = 0.041) between patients with positive and negative sIgG antibodies. Patients with multiple positive allergens (≥ 3) were especially found with significant higher total IgG levels compared with sIgG-negative patients (P = 0.003). Age was suggested as a protective factor against the occurrence of sIgG antibodies (P = 0.002).
conclusionsThe study demonstrates a high prevalence of serum IgG antibodies to specific food allergens in patients with IBD. sIgG antibodies may potentially indicate disease status in clinical and be utilized to guide diets for patients.
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