ArticlePloS one2014
Fluconazole alters the polysaccharide capsule of Cryptococcus gattii and leads to distinct behaviors in murine Cryptococcosis.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Anticryptococcal Evaluation of the Allylimine 3H2: Modulation of Virulence Traits and Synergistic Action with Amphotericin B.ACS omega · 2026Article
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- Comparative Analysis of Capsular and Secreted Polysaccharides Produced byJournal of fungi (Basel, Switzerland) · 2023Article
- The Th2 Response and Alternative Activation of Macrophages Triggered byJournal of fungi (Basel, Switzerland) · 2023Article
- Fluconazole Resistance and Virulence in In Vitro Induced-Fluconazole Resistant Strains and in Clinical Fluconazole Resistant Strain ofPathogens (Basel, Switzerland) · 2023Article
- The Dynamics ofCells · 2022Article
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- Fungicide effects on human fungal pathogens: Cross-resistance to medical drugs and beyond.PLoS pathogens · 2021Review
- Article
- A phenylthiazole derivative demonstrates efficacy on treatment of the cryptococcosis & candidiasis in animal models.Future science OA · 2018Article
- Environmental Triazole Induces Cross-Resistance to Clinical Drugs and Affects Morphophysiology and Virulence of Cryptococcus gattii and C. neoformans.Antimicrobial agents and chemotherapy · 2018Article
- High-dose fluconazole in combination with amphotericin B is more efficient than monotherapy in murine model of cryptococcosis.Scientific reports · 2017Article
- Eugenol Induces Phenotypic Alterations and Increases the Oxidative Burst inFrontiers in microbiology · 2017Article
- Influenza A Virus as a Predisposing Factor for Cryptococcosis.Frontiers in cellular and infection microbiology · 2017Article
- Treatment with pCramoll Alone and in Combination with Fluconazole Provides Therapeutic Benefits inFrontiers in cellular and infection microbiology · 2017Article
- Impact of Resistance to Fluconazole on Virulence and Morphological Aspects of Cryptococcus neoformans and Cryptococcus gattii Isolates.Frontiers in microbiology · 2016Article
- Heteroresistance to Itraconazole Alters the Morphology and Increases the Virulence of Cryptococcus gattii.Antimicrobial agents and chemotherapy · 2015Article
- Synthesis of a New Peptide-Coumarin Conjugate: A Potential Agent against Cryptococcosis.ACS medicinal chemistry letters · 2015Article
- Article
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Authors and funding
21 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cryptococcus gattii is an emergent human pathogen. Fluconazole is commonly used for treatment of cryptococcosis, but the emergence of less susceptible strains to this azole is a global problem and also the data regarding fluconazole-resistant cryptococcosis are scarce. We evaluate the influence of fluconazole on murine cryptococcosis and whether this azole alters the polysaccharide (PS) from cryptococcal cells. L27/01 strain of C. gattii was cultivated in high fluconazole concentrations and developed decreased drug susceptibility. This phenotype was named L27/01F, that was less virulent than L27/01 in mice. The physical, structural and electrophoretic properties of the PS capsule of L27/01F were altered by fluconazole. L27/01F presented lower antiphagocytic properties and reduced survival inside macrophages. The L27/01F did not affect the central nervous system, while the effect in brain caused by L27/01 strain began after only 12 hours. Mice infected with L27/01F presented lower production of the pro-inflammatory cytokines, with increased cellular recruitment in the lungs and severe pulmonary disease. The behavioral alterations were affected by L27/01, but no effects were detected after infection with L27/01F. Our results suggest that stress to fluconazole alters the capsule of C. gattii and influences the clinical manifestations of cryptococcosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.