ArticleAdvances in aging research2013
Increased vitamin D is associated with decline of naïve, but accumulation of effector, CD8 T cells during early aging.
Article in Advances in aging research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- The 1α,25-dihydroxyvitamin D3 modulates T cell activation and immune checkpoint pathways in human T cells.Frontiers in immunology · 2026Article
- The Hidden Pathway: Membrane Vitamin D Receptor Deficiency and T-Cell Senescence in Pediatric Atopic Dermatitis - A Retrospective and Cross-Sectional Investigation.Journal of asthma and allergy · 2026Article
- Vitamin D and colorectal cancer: Chemopreventive perspectives through the gut microbiota and the immune system.BioFactors (Oxford, England) · 2022Review
- Vitamin D levels and oxidative stress markers in patients hospitalized with COVID-19.Redox report : communications in free radical research · 2021Article
- Evaluation of selected immunological parameters and the concentration of vitamin D in children with asthma. Case-control study.Central-European journal of immunology · 2017Article
- Effects of high doses of vitamin D3 on mucosa-associated gut microbiome vary between regions of the human gastrointestinal tract.European journal of nutrition · 2016Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Given the protective roles of 25-hydroxyvitamin D (25[OH]D or vitamin D) in musculoskeletal health and the potential beneficial effects of vitamin D supplementation in reducing the risk of various chronic diseases, intensive repletion of vitamin D has been widely advocated. Of note, CD8 T cells have the highest levels of the vitamin D receptor compared with other major immune cells. The effects of vitamin D on CD8 T cells during aging, however, remain unclear. This study determined the relationship between vitamin D levels and CD8 T-cell status in 34 healthy female subjects (all >60 years old). The CD8 T cell phenotype was defined by the surface expression of CD28 and CD95. The low-25(OH)D serum groups (≤30 ng/ml) had higher percentages of CD28
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Registered trials
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