Evidence map›Paper›PMID 25392748›Full record

ArticleJournal of gerontology & geriatric research2014

Testosterone Supplementation Improves Carbohydrate and Lipid Metabolism in Some Older Men with Abdominal Obesity.

Fr Sattler, J He, J Chukwuneke, H Kim, Y Stewart, P Colletti, Ke Yarasheski, Ta Buchanan

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of gerontology & geriatric research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00365794 (Investigator Initiated Study of the Effects of Androgen Therapy on Carbohydrate and Lipid Metabolism In Elderly Men), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00365794 phase2completednot on this map

Investigator Initiated Study of the Effects of Androgen Therapy on Carbohydrate and Lipid Metabolism In Elderly Men

TypeinterventionalSponsorUniversity of Southern CaliforniaRan2006 to 2014Enrolled22ConditionsAging, Obesity, Insulin Resistance, HypogonadismArmsTopical testosterone gel 10 g/day
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Fr SattlerDepartment of Medicine, University of Southern California, Los Angeles, CA, USA.
J HeDepartment of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.
J ChukwunekeDepartment of Medicine, University of Southern California, Los Angeles, CA, USA.
H KimDepartment of Radiology, University of Southern California, Los Angeles, CA, USA.
Y StewartDepartment of Medicine, University of Southern California, Los Angeles, CA, USA.
P CollettiDepartment of Radiology, University of Southern California, Los Angeles, CA, USA.
Ke YarasheskiDepartment of Medicine, Washington University, St. Louis, MO, USA.
Ta BuchananDepartment of Medicine, University of Southern California, Los Angeles, CA, USA.
University of Southern California · US

Funding

ZOPOLRESTAT IN NORMOTENSIVE, TYPE 1 DIA WITH INCIPIENT NEPHROPATHYM01RR000043 · NCRR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZAIA, JOHN A · 1985 to 2010
$76.4M
Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Brian N Finck · 1999 to 2026
$30.2M
WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Jennifer Lynn Powers Carson · 2013 to 2026
$27.1M
YOGA LIFESTYLE INTERVENTION REDUCES BLOOD PRESSURE IN HIV-INFECTED ADULTSP41RR000954 · NCRR · WASHINGTON UNIVERSITY · PI GROSS, MICHAEL L · 1985 to 2011
$16.0M
TrainingP41GM103422 · NIGMS · WASHINGTON UNIVERSITY · PI YARASHESKI, KEVIN E · 2012 to 2019
$12.0M
HORMONAL REGULATORS OF MUSCLE AND METABOLISM IN AGINGR01AG018169 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SATTLER, FRED R · 2002 to 2005
$3.2M
NCRR NIH HHS M01 RR000043NCRR NIH HHS P41 RR000954NIA NIH HHS R01 AG018169NIDDK NIH HHS P30 DK020579NIDDK NIH HHS P30 DK056341NIGMS NIH HHS P41 GM103422
6 · The paper itself

Abstract

BACKGROUND/

objectivesThe effects of testosterone supplementation on carbohydrate and lipid metabolism in obese older men are uncertain. We conducted a single-arm open-label prospective pilot study to investigate the effects of testosterone supplementation on central and peripheral insulin sensitivity in older men with upper body obesity and insulin resistance. SUBJECTS/

methodsTwenty men (62-78 years-old) with morning testosterone levels <13.9 nmol/L (400 ng/dL), waist circumference ≥ 102 cm, and HOMA-IR ≥ 4.0 or HgbA1C 5.7-6.4% applied transdermal testosterone (10 mg) daily for 20 weeks. Insulin sensitivity (Si) was determined by a 2-stage glucose clamp, liver and intramyocellular lipid by

resultsTestosterone supplementation significantly reduced total fat (-.9 ± 2.4 kg, p=0.002), trunk fat (-1.3 ± 1.4 kg, p=0.0007) and extremity fat (-0.7 ± 1.1 kg, p=0.01), and increased extremity lean tissue (+1.3 ± 1.4 kg, p=0.0006). Whole body (WB) Si improved by 21% (0.76 ± 1.57 dL/min per µU/mL, p=0.04) and insulin-stimulated glucose uptake (Rd) by 24% (0.91 ± 1.74 dL/min per µU/mL, p=0.03). Improvements in glucose kinetics were limited to men with reductions in trunk and extremity fat greater than median declines for the entire group. Reductions in intramyocellular lipid were associated with improvements in WB Si (p=0.04) and Rd (p=0.03). Change in Rd accounted for 90% of the change in WB Si. Hepatic glucose output and liver lipid/H

conclusionsTestosterone supplementation that resulted in greater reductions in regional adiposity was associated with improved insulin sensitivity, lower LDL-C and fasting triglycerides, but lower HDL-C. Placebo controlled trials need to further examine the potential cardiometabolic risks/benefits of androgen supplementation for older men with low testosterone levels, central obesity, and insulin resistance.

Indexed as

AgingInsulin resistanceMetabolismObesityTestosterone

Identifiers

PMID25392748
PMCPMC4225803
OpenAlexW2082192489

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.