ArticleThe annals of applied statistics2014
VOXEL-LEVEL MAPPING OF TRACER KINETICS IN PET STUDIES: A STATISTICAL APPROACH EMPHASIZING TISSUE LIFE TABLES.
Article in The annals of applied statistics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Parametric imaging of dynamic long-axial-field-of-view PET scans: Technical challenges, statistical insights and clinical applications.Zeitschrift fur medizinische Physik · 2026Review
- MappingJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024Article
- Single-voxel delay map from long-axial field-of-view PET scans.Frontiers in nuclear medicine · 2024Article
- Quantitation of dynamic total-body PET imaging: recent developments and future perspectives.European journal of nuclear medicine and molecular imaging · 2023Review
- PET AIF estimation when available ROI data is impacted by dispersive and/or background effects.Physics in medicine and biology · 2023Article
- Astrocyte activation imaging with 11C-acetate and amyloid PET in mild cognitive impairment due to Alzheimer pathology.Nuclear medicine communications · 2021Article
- A Generalized Linear modeling approach to bootstrapping multi-frame PET image data.Medical image analysis · 2021Article
- Quantitation of multiple injection dynamic PET scans: an investigation of the benefits of pooling data from separate scans when mapping kinetics.Physics in medicine and biology · 2021Article
- Analysis of Four-Dimensional Data for Total Body PET Imaging.PET clinics · 2021Review
- Imaging Cancer Metabolism: Underlying Biology and Emerging Strategies.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2018Review
- Assessment of a statistical AIF extraction method for dynamic PET studies withJournal of medical imaging (Bellingham, Wash.) · 2018Article
- Statistical assessment of treatment response in a cancer patient based on pre-therapy and post-therapy FDG-PET scans.Statistics in medicine · 2017Article
- A Functional Approach to Deconvolve Dynamic Neuroimaging Data.Journal of the American Statistical Association · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Most radiotracers used in dynamic positron emission tomography (PET) scanning act in a linear time-invariant fashion so that the measured time-course data are a convolution between the time course of the tracer in the arterial supply and the local tissue impulse response, known as the tissue residue function. In statistical terms the residue is a life table for the transit time of injected radiotracer atoms. The residue provides a description of the tracer kinetic information measurable by a dynamic PET scan. Decomposition of the residue function allows separation of rapid vascular kinetics from slower blood-tissue exchanges and tissue retention. For voxel-level analysis, we propose that residues be modeled by mixtures of nonparametrically derived basis residues obtained by segmentation of the full data volume. Spatial and temporal aspects of diagnostics associated with voxel-level model fitting are emphasized. Illustrative examples, some involving cancer imaging studies, are presented. Data from cerebral PET scanning with
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.