ArticleNutrition & metabolism2014
Protein energy malnutrition increases arginase activity in monocytes and macrophages.
Article in Nutrition & metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- The value of perioperative nutritional risk stratification in the prevention of surgical site infection: precision application from GLIM/PG-SGA to PNI, CONUT, and GNRI.Frontiers in nutrition · 2026Review
- Ineffective Recanalization and Complications in Patients with Acute Ischemic Stroke Receiving Endovascular Treatment: Predictive Value of the c-Reactive Protein-Albumin-Lymphocyte (CALLY) Index.Journal of inflammation research · 2025Article
- Low protein diet protects the liver from Salmonella Typhimurium-mediated injury by modulating the mTOR/autophagy axis in macrophages.Communications biology · 2024Article
- A New Murine Undernutrition Model Based on Complementary Feeding of Undernourished Children Causes Damage to the Morphofunctional Intestinal Epithelium Barrier.The Journal of nutrition · 2024Article
- Upregulation of PD-1/PD-L1 and downregulation of immune signaling pathways lead to more severe visceral leishmaniasis in undernutrition mice.Parasites & vectors · 2024Article
- Malnutrition-related parasite dissemination from the skin in visceral leishmaniasis is driven by PGE2-mediated amplification of CCR7-related trafficking of infected inflammatory monocytes.PLoS neglected tropical diseases · 2023Article
- Relationship between Mini Nutritional Assessment Score and Infection in Critical Care Patients.Medical journal of the Islamic Republic of Iran · 2022Article
- Determinants of severe acute malnutrition among children aged 6-59 months in the pastoral community of Liban District, Guji Zone, Oromia Regional State, Southeastern Ethiopia: a case-control study.Journal of nutritional science · 2021Article
- Validation of a Feed Protocol in a Mouse Model That Mimics Marasmic Malnutrition.Frontiers in veterinary science · 2021Article
- Nutritional Intake and Chronicity Associated with the Old World Cutaneous Leishmaniasis: Role of Vitamin A.Iranian journal of public health · 2020Article
- Animal Models of Undernutrition and Enteropathy as Tools for Assessment of Nutritional Intervention.Nutrients · 2019Review
- Metabolic programming of macrophage functions and pathogens control.Redox biology · 2019Review
- Malnutrition in Healthy Individuals Results in Increased Mixed Cytokine Profiles, Altered Neutrophil Subsets and Function.PloS one · 2016Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProtein energy malnutrition is commonly associated with immune dysfunctions and is a major factor in susceptibility to infectious diseases.
methodsIn this study, we evaluated the impact of protein energy malnutrition on the capacity of monocytes and macrophages to upregulate arginase, an enzyme associated with immunosuppression and increased pathogen replication.
resultsOur results show that monocytes and macrophages are significantly increased in the bone marrow and blood of mice fed on a protein low diet. No alteration in the capacity of bone marrow derived macrophages isolated from malnourished mice to phagocytose particles, to produce the microbicidal molecule nitric oxide and to kill intracellular Leishmania parasites was detected. However, macrophages and monocytes from malnourished mice express significantly more arginase both in vitro and in vivo. Using an experimental model of visceral leishmaniasis, we show that following protein energy malnutrition, the increased parasite burden measured in the spleen of these mice coincided with increased arginase activity and that macrophages provide a more permissive environment for parasite growth.
conclusionsTaken together, these results identify a novel mechanism in protein energy malnutrition that might contributes to increased susceptibility to infectious diseases by upregulating arginase activity in myeloid cells.
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