ArticleCancer informatics2014
Mining cancer-specific disease comorbidities from a large observational health database.
Article in Cancer informatics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Applications of network analysis to routinely collected health care data: a systematic review.Journal of the American Medical Informatics Association : JAMIA · 2018Pooled it
- Comorbidities associated with fetal alcohol spectrum disorders in the United States.Scientific reports · 2025Article
- Comorbidity in Older Patients Hospitalized with Cancer in Northeast China based on Hospital Discharge Data.International journal of environmental research and public health · 2020Article
- Sensitivity of comorbidity network analysis.JAMIA open · 2020Article
- Mental Health Comorbidity Analysis in Pediatric Patients with Autism Spectrum Disorder Using Rhode Island Medical Claims Data.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2020Article
- Large-scale mining disease comorbidity relationships from post-market drug adverse events surveillance data.BMC bioinformatics · 2018Article
- Context-sensitive network-based disease genetics prediction and its implications in drug discovery.Bioinformatics (Oxford, England) · 2017Article
- Interrogating Patient-level Genomics and Mouse Phenomics towards Understanding Cytokines in Colorectal Cancer Metastasis.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2017Article
- Phenome-based gene discovery provides information about Parkinson's disease drug targets.BMC genomics · 2016Article
- Insights into Population Health Management Through Disease Diagnoses Networks.Scientific reports · 2016Article
- Phenome-driven disease genetics prediction toward drug discovery.Bioinformatics (Oxford, England) · 2015Article
- Disease Comorbidity Network Guides the Detection of Molecular Evidence for the Link Between Colorectal Cancer and Obesity.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2015Article
- Multimorbidity and mortality: A data science perspective.Journal of multimorbidity and comorbidityArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cancer comorbidities often reflect the complex pathogenesis of cancers and provide valuable clues to discover the underlying genetic mechanisms of cancers. In this study, we systematically mine and analyze cancer-specific comorbidity from the FDA Adverse Event Reporting System. We stratified 3,354,043 patients based on age and gender, and developed a network-based approach to extract comorbidity patterns from each patient group. We compared the comorbidity patterns among different patient groups and investigated the effect of age and gender on cancer comorbidity patterns. The results demonstrated that the comorbidity relationships between cancers and non-cancer diseases largely depend on age and gender. A few exceptions are depression, anxiety, and metabolic syndrome, whose comorbidity relationships with cancers are relatively stable among all patients. Literature evidences demonstrate that these stable cancer comorbidities reflect the pathogenesis of cancers. We applied our comorbidity mining approach on colorectal cancer and detected its comorbid associations with metabolic syndrome components, diabetes, and osteoporosis. Our results not only confirmed known cancer comorbidities but also generated novel hypotheses, which can illuminate the common pathophysiology between cancers and their co-occurring diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.