Evidence map›Paper›PMID 25392649›Full record

Trial reportJSLS : Journal of the Society of Laparoendoscopic Surgeons

Antimullerian hormone level and endometrioma ablation using plasma energy.

Horace Roman, Michael Bubenheim, Mathieu Auber, Loïc Marpeau, Lucian Puscasiu

2 registry-linked trialsOpen access · hybridAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in JSLS : Journal of the Society of Laparoendoscopic Surgeons. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01596985 phase2unknown statusnot on this map

Prospective, Monocentric Study Comparing Cystectomy to PlasmaJet Ablation in the Surgical Management of Ovarian Endometriomas

TypeinterventionalSponsorPlasma Surgical IncRan2010 to 2013Enrolled50ConditionsOvarian EndometriomaArmsAblation using the PlasmaJet system, Cystectomy
NCT02294825 unknown statusnot on this map

The North-West Inter Regional Female Cohort for Patients With Endometriosi

Typeobservational_patient_registrySponsorUniversity Hospital, RouenRan2009 to 2022Enrolled1,500ConditionsEndometriosisArmsvarious surgical procedures in endometriosis
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 38 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Article
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Horace RomanDepartment of Gynecology and Obstetrics, Rouen University Hospital, Rouen, France, Research Group 4308 ≪ Spermatogenesis and Gamete Quality≫, IHU Rouen Normandy, IFRMP23, Reproductive Biology Laboratory, Rouen University Hospital, Rouen, France.
Michael BubenheimDepartment of Statistics, Rouen University Hospital, Rouen, France.
Mathieu AuberDepartment of Gynecology and Obstetrics, Rouen University Hospital, Rouen, France, Research Group 4308 ≪ Spermatogenesis and Gamete Quality≫, IHU Rouen Normandy, IFRMP23, Reproductive Biology Laboratory, Rouen University Hospital, Rouen, France.
Loïc MarpeauDepartment of Gynecology and Obstetrics, Rouen University Hospital, Rouen, France, Research Group 4308 ≪ Spermatogenesis and Gamete Quality≫, IHU Rouen Normandy, IFRMP23, Reproductive Biology Laboratory, Rouen University Hospital, Rouen, France.
Lucian PuscasiuDepartment of Gynecology and Obstetrics, University Hospital, Targu Mures, Romania.
Spitalul Clinic Judetean de Urgenta Târgu Mureş · ROUniversité de Rouen Normandie · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the impact of ovarian endometrioma vaporization using plasma energy on antimullerian hormone (AMH) level.

methodWe report a prospective, noncomparative series (NCT01596985). Twenty-two patients with unilateral ovarian endometriomas≥30 mm, with no surgical antecedent and no ongoing pregnancy, underwent vaporization of ovarian endometriomas using plasma energy during the period of November 29, 2010 to November 28, 2012. We assessed AMH levels before surgery, 3 months postoperatively, and at the end of follow-up.

resultsThe mean length of postoperative follow-up was 18.2±8 months. AMH level significantly varied through the 3 assessments performed in the study, as the mean values±SD were 3.9±2.6 ng/mL before the surgery, 2.3±1.1 ng/mL at 3 months, and 3.1±2.2 ng/mL at the end of the follow-up (P=.001). There was a significant increase from 3 months postoperatively to the end of follow-up (median change 0.7 ng/mL, P=.01). Seventy-one percent of patients had an AMH level>2 ng/mL at the end of the follow-up versus 76% before the surgery (P=1). During the postoperative follow-up, 11 patients tried to conceive, of whom 8 (73%) became pregnant.

conclusionsThe ablation of unilateral endometriomas is followed in a majority of cases by a significant decrease in AMH level 3 months after surgery. In subsequent months, this level progressively increases, raising questions about the real factors that impact postoperative ovarian AMH production.

Indexed as

Ablation TechniquesAdultAnti-Mullerian HormoneBiomarkers, TumorEndometriosisFemaleHumansLaparoscopyOvarian NeoplasmsPregnancyProspective StudiesAnti-Mullerian HormoneBiomarkers, TumorAblationAntimullerian hormoneEndometriomaPlasma energyPlasmaJetVaporization

Identifiers

PMID25392649
PMCPMC4208885
OpenAlexW2326315293

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.