Evidence map›Paper›PMID 25392594›Full record

ArticleAfrican journal of traditional, complementary, and alternative medicines : AJTCAM2014

Evaluation of three medicinal plant extracts against Plasmodium falciparum and selected microganisms.

Abiodun Falodun, Vincent Imieje, Osayewenre Erharuyi, Joy Ahomafor, Melissa R Jacob, Shabana I Khan, Mark T Hamann

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in African journal of traditional, complementary, and alternative medicines : AJTCAM, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Protective Role ofAdvances in pharmacological and pharmaceutical sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Abiodun FalodunDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Benin City, Nigeria ; Department of Pharmacognosy, School of Pharmacy, University, University of Mississippi, MS 38655, USA.
Vincent ImiejeDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Benin City, Nigeria ; Institute of Organic Chemistry, University of Restock, 18509, Restock, Germany.
Osayewenre ErharuyiDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Benin City, Nigeria ; Institute of Organic Chemistry, University of Restock, 18509, Restock, Germany.
Joy AhomaforDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Benin City, Nigeria.
Melissa R JacobCenter for for Natural Products Research, School of Pharmacy, University of Mississippi, MS, 38677, USA.
Shabana I KhanCenter for for Natural Products Research, School of Pharmacy, University of Mississippi, MS, 38677, USA.
Mark T HamannDepartment of Pharmacognosy, School of Pharmacy, University, University of Mississippi, MS 38655, USA.

Funding

NEW DRUGS FOR OPPORTUNISTIC INFECTIOUS DISEASESR01AI027094 · NIAID · UNIVERSITY OF MISSISSIPPI · PI CLARK, ALICE M. · 1989 to 2013
$4.4M
Natural Product HCV Drugs from Rare Plant-Microbe InteractionsR01AT007318 · NCCIH · UNIVERSITY OF MISSISSIPPI · PI HAMANN, MARK T · 2012 to 2016
$1.6M
NCCIH NIH HHS R01 AT007318NIAID NIH HHS AI 27094NIAID NIH HHS R01 AI027094
6 · The paper itself

Abstract

backgroundA great revival of scientific interests in drug discovery has been witnessed in recent years from medicinal plants for health maintenance. The aim of this work was to investigate three Nigerian medicinal plants collected in Nigeria for their in vitro antiplasmodial and antimicrobial activities. MATERIALS AND

methodsExtracts obtained from parts of Persea americana, Jatropha podagrica and Picralima nitida and their fractions were evaluated for in vitro antiprotozoal and antimicrobial activity.

resultThe methanol extract of P. nitida demonstrated activity against chloroquine-sensitive and chloroquine-resistant P. falciparum clones with IC50 values of 6.3 and 6.0 µg/mL, respectively. Methanol and chloroform extracts of P. americana seed showed antifungal activity against Cryptococcus neoformans IC50 less than 8 and 8.211 µg/mL respectively. Finally, the petroleum ether extract of P. americana had activity against methicillin-resistant Staphylococcus aureus (MRSA) with an IC50 value of 8.7 µg/mL.

conclusionThe study revealed the antibacterial and antiplasmodial activities of the plants extracts at the tested concentrations.

Indexed as

ApocynaceaeJatrophaPerseaAnti-Bacterial AgentsAntifungal AgentsAnti-Infective AgentsAntiprotozoal AgentsCryptococcusMethicillin-Resistant Staphylococcus aureusPlant ExtractsPlants, MedicinalPlasmodium falciparumAnti-Bacterial AgentsAntifungal AgentsAnti-Infective AgentsAntiprotozoal AgentsPlant ExtractsAntibacterialAntifungalJatropha podagricaPersea americanaPicralima nitidaPlasmodium falciparum

Identifiers

PMID25392594
PMCPMC4202410

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.