ArticleAfrican journal of traditional, complementary, and alternative medicines : AJTCAM2014
Izalpinin from fruits of Alpinia oxyphylla with antagonistic activity against the rat bladder contractility.
Article in African journal of traditional, complementary, and alternative medicines : AJTCAM, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed.
- Identification of Chemical Constituents from Leaves and Stems ofAntioxidants (Basel, Switzerland) · 2024Article
- Medicinal plants and natural products for treating overactive bladder.Chinese medicine · 2024Review
- Microbial Transformation of Yakuchinone A and Cytotoxicity Evaluation of Its Metabolites.International journal of molecular sciences · 2022Article
- Exploring the Use ofAntioxidants (Basel, Switzerland) · 2022Review
- Analysis of Bioactive Components in the Fruit, Roots, and Leaves ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Chemical Diversity and Biological Activity of African Propolis.Progress in the chemistry of organic natural products · 2019Article
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9 authors.
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Abstract
backgroundAlpinia oxyphylla (Zingiberaceae), an herbaceous perennial plant, its capsular fruit is commonly used in traditional Chinese medicine for the treatment of different urinary incontinence symptoms including frequency, urgency and nocturia. These symptoms are similar to the overactive bladder syndrome. In our lab, we found that the 95% ethanol extract of the capsular fruits exhibited significant anti-muscarinic activity. Some constituents in capsular fruits including flavonoids (e.g., izalpinin and tectochrysin), diarylheptanoids (e.g., yakuchinone A and yakuchinone B) and sesquiterpenes (e.g., nootkatone), are regarded as representative chemicals with putative pharmacological activities.
objectiveThis study aimed to evaluate the in vitro antagonistic actions of izalpinin on carbachol-induced contraction of the rat detrusor muscle. MATERIALS AND
methodsIn vitro inhibition of rat detrusor contractile response to carbachol was used to study the functional activity of izalpinin. The isolated detrusor strips of rats were mounted in organ baths containing oxygenated Krebs' solution. The cumulative consecutive concentration-response curves to carbachol-evoked contractions in strips of rat bladder were obtained.
resultsCarbachol induced concentration-dependent contractions of isolated rat bladder detrusor strips. The vehicle DMSO had no impact on the contraction response. The contraction effects were concentration-dependently antagonized by izalpinin, with a mean EC50 value of 0.35 µM. The corresponding cumulative agonist concentration-response curves shifted right-ward.
conclusionsIzalpinin exhibits inhibitory role of muscarinic receptor-related detrusor contractile activity, and it may be a promising lead compound to treat overactive bladder.
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