ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Target-specific properties of thalamocortical synapses onto layer 4 of mouse primary visual cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed, 98 citations in OpenAlex.
- Convergence and function of distinct corticocortical and transthalamic synapses across sensory processing hierarchies.bioRxiv : the preprint server for biology · 2026Article
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- The Logic of Thalamic Inputs onto the Molecular Taxonomy of Cortical Neurons Reveals a Visual Hierarchy.bioRxiv : the preprint server for biology · 2026Article
- Multiplexed changes in synaptic transmission underlie stress-induced reduction of persistent firing in the parietal cortex.Progress in neurobiology · 2026Article
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- Post-Critical Period Transcriptional and Physiological Adaptations of Primary Sensory Cortex after Sensory Loss.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Review
- Neuronal subtype-dependent kinetics of EPSCs induced by thalamocortical projections from the ventroposteromedial thalamic nucleus to the insular cortex in rats.Pflugers Archiv : European journal of physiology · 2025Article
- Understanding the molecular diversity of synapses.Nature reviews. Neuroscience · 2025Review
- Inhibitory Gating of Thalamocortical Inputs onto Rat Gustatory Insular Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Article
- Altered Thalamocortical Signaling in a Mouse Model of Parkinson's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Precise movement-based predictions in the mouse auditory cortex.Current biology : CB · 2022Article
- Cre driver mouse lines for thalamocortical circuit mapping.The Journal of comparative neurology · 2022Article
- Thalamic bursts modulate cortical synchrony locally to switch between states of global functional connectivity in a cognitive task.PLoS computational biology · 2022Article
- VIP-Expressing GABAergic Neurons: Disinhibitory vs. Inhibitory Motif and Its Role in Communication Across Neocortical Areas.Frontiers in cellular neuroscience · 2022Review
- State-Dependent Regulation of Cortical Processing Speed via Gain Modulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Portrait of visual cortical circuits for generating neural oscillation dynamics.Cognitive neurodynamics · 2021Review
- Stimulus-Selective Response Plasticity in Primary Visual Cortex: Progress and Puzzles.Frontiers in neural circuits · 2021Review
1 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
In primary sensory cortices, thalamocortical (TC) inputs can directly activate excitatory and inhibitory neurons. In vivo experiments in the main input layer (L4) of primary visual cortex (V1) have shown that excitatory and inhibitory neurons have different tuning properties. The different functional properties may arise from distinct intrinsic properties of L4 neurons, but could also depend on cell type-specific properties of the synaptic inputs from the lateral geniculate nucleus of the thalamus (LGN) onto L4 neurons. While anatomical studies identified LGN inputs onto both excitatory and inhibitory neurons in V1, their synaptic properties have not been investigated. Here we used an optogenetic approach to selectively activate LGN terminal fields in acute coronal slices containing V1, and recorded monosynaptic currents from excitatory and inhibitory neurons in L4. LGN afferents made monosynaptic connections with pyramidal (Pyr) and fast-spiking (FS) neurons. TC EPSCs on FS neurons were larger and showed steeper short-term depression in response to repetitive stimulation than those on Pyr neurons. LGN inputs onto Pyr and FS neurons also differed in postsynaptic receptor composition and organization of presynaptic release sites. Together, our results demonstrate that LGN input onto L4 neurons in mouse V1 have target-specific presynaptic and postsynaptic properties. Distinct mechanisms of activation of feedforward excitatory and inhibitory neurons in the main input layer of V1 are likely to endow neurons with different response properties to incoming visual stimuli.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.