ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Auditory cortex is required for fear potentiation of gap detection.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Neural mechanisms of fear memory precision and generalization: from auditory cortex to amygdala.Translational psychiatry · 2026Review
- Noise-invariant representations of sound emerge along the canonical cortical hierarchy.PLoS biology · 2026Article
- An auditory cortical-striatal circuit supports sound-triggered timing to predict future events.PLoS biology · 2025Article
- A genetically identified population of layer 4 neurons in auditory cortex that contributes to pre-pulse inhibition of the acoustic startle response.Frontiers in neural circuits · 2022Article
- What can we learn from inactivation studies? Lessons from auditory cortex.Trends in neurosciences · 2022Review
- Parvalbumin-Positive Interneurons Regulate Cortical Sensory Plasticity in Adulthood and Development Through Shared Mechanisms.Frontiers in neural circuits · 2022Review
- Article
- GABAergic microcircuitry of fear memory encoding.Neurobiology of learning and memory · 2021Review
- A role of oligodendrocytes in information processing.Nature communications · 2020Article
- 5XFAD mice show early-onset gap encoding deficits in the auditory cortex.Neurobiology of aging · 2020Article
- A Cortico-Collicular Amplification Mechanism for Gap Detection.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Primary auditory cortex representation of fear-conditioned musical sounds.Human brain mapping · 2020Article
- A Layer 3→5 Circuit in Auditory Cortex That Contributes to Pre-pulse Inhibition of the Acoustic Startle Response.Frontiers in neural circuits · 2020Article
- Embracing Complexity in Defensive Networks.Neuron · 2019Review
- Disruption of Early or Late Epochs of Auditory Cortical Activity Impairs Speech Discrimination in Mice.Frontiers in neuroscience · 2019Article
- Neural Correlates of Learning Pure Tones or Natural Sounds in the Auditory Cortex.Frontiers in neural circuits · 2019Article
- 5XFAD Mice Show Early Onset Gap Detection Deficits.Frontiers in aging neuroscience · 2019Article
- Gap encoding by parvalbumin-expressing interneurons in auditory cortex.Journal of neurophysiology · 2018Article
- Article
- Acoustic startle modification as a tool for evaluating auditory function of the mouse: Progress, pitfalls, and potential.Neuroscience and biobehavioral reviews · 2017Review
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4 authors.
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Abstract
Auditory cortex is necessary for the perceptual detection of brief gaps in noise, but is not necessary for many other auditory tasks such as frequency discrimination, prepulse inhibition of startle responses, or fear conditioning with pure tones. It remains unclear why auditory cortex should be necessary for some auditory tasks but not others. One possibility is that auditory cortex is causally involved in gap detection and other forms of temporal processing in order to associate meaning with temporally structured sounds. This predicts that auditory cortex should be necessary for associating meaning with gaps. To test this prediction, we developed a fear conditioning paradigm for mice based on gap detection. We found that pairing a 10 or 100 ms gap with an aversive stimulus caused a robust enhancement of gap detection measured 6 h later, which we refer to as fear potentiation of gap detection. Optogenetic suppression of auditory cortex during pairing abolished this fear potentiation, indicating that auditory cortex is critically involved in associating temporally structured sounds with emotionally salient events.
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