ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Visualizing the engram: learning stabilizes odor representations in the olfactory network.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 26 citations in OpenAlex.
- Single Inhalation of Peppermint Essential Oil Alleviates Acute Restraint Stress-Exacerbated Itch in Oxazolone-Induced Mild Dermatitis: Correlations With Brain Neuronal Activity in Female BALB/c Mouse.Brain and behavior · 2025Article
- Acquisition of non-olfactory encoding improves odour discrimination in olfactory cortex.Nature communications · 2024Article
- Memory Storage in Distributed Engram Cell Ensembles.Advances in neurobiology · 2024Review
- Dynamic developmental changes in neurotransmitters supporting infant attachment learning.Neuroscience and biobehavioral reviews · 2023Review
- Tissue clearing applications in memory engram research.Frontiers in behavioral neuroscience · 2023Review
- Brain-wide mapping reveals that engrams for a single memory are distributed across multiple brain regions.Nature communications · 2022Article
- Cortical feedback and gating in odor discrimination and generalization.PLoS computational biology · 2021Article
- Learning-induced mRNA alterations in olfactory bulb mitral cells in neonatal rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- Associative conditioning remaps odor representations and modifies inhibition in a higher olfactory brain area.Nature neuroscience · 2019Article
- Pheromone-Induced Odor Associative Fear Learning in Rats.Scientific reports · 2018Article
- Sodium and potassium conductances in principal neurons of the mouse piriform cortex: a quantitative description.The Journal of physiology · 2018Article
- TrpM8-mediated somatosensation in mouse neocortex.The Journal of comparative neurology · 2018Article
- Piriform cortical glutamatergic and GABAergic neurons express coordinated plasticity for whisker-induced odor recall.Oncotarget · 2017Article
- Experience-Dependent Plasticity in Accessory Olfactory Bulb Interneurons following Male-Male Social Interaction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Learning-Induced Metaplasticity? Associative Training for Early Odor Preference Learning Down-Regulates Synapse-Specific NMDA Receptors via mGluR and Calcineurin Activation.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- CaMKII mediates stimulus specificity in early odor preference learning in rats.Journal of neurophysiology · 2016Article
- Watching a memory form-VSD imaging reveals a novel memory mechanism.Communicative & integrative biology · 2016Article
- Arc-Expressing Neuronal Ensembles Supporting Pattern Separation Require Adrenergic Activity in Anterior Piriform Cortex: An Exploration of Neural Constraints on Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Computational modeling suggests distinct, location-specific function of norepinephrine in olfactory bulb and piriform cortex.Frontiers in computational neuroscience · 2015Article
- Norepinephrine Modulates Pyramidal Cell Synaptic Properties in the Anterior Piriform Cortex of Mice: Age-Dependent Effects of β-adrenoceptors.Frontiers in cellular neuroscience · 2015Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
The nature of memory is a central issue in neuroscience. How does our representation of the world change with learning and experience? Here we use the transcription of Arc mRNA, which permits probing the neural representations of temporally separated events, to address this in a well characterized odor learning model. Rat pups readily associate odor with maternal care. In pups, the lateralized olfactory networks are independent, permitting separate training and within-subject control. We use multiday training to create an enduring memory of peppermint odor. Training stabilized rewarded, but not nonrewarded, odor representations in both mitral cells and associated granule cells of the olfactory bulb and in the pyramidal cells of the anterior piriform cortex. An enlarged core of stable, likely highly active neurons represent rewarded odor at both stages of the olfactory network. Odor representations in anterior piriform cortex were sparser than typical in adult rat and did not enlarge with learning. This sparser representation of odor is congruent with the maturation of lateral olfactory tract input in rat pups. Cortical representations elsewhere have been shown to be highly variable in electrophysiological experiments, suggesting brains operate normally using dynamic and network-modulated representations. The olfactory cortical representations here are consistent with the generalized associative model of sparse variable cortical representation, as normal responses to repeated odors were highly variable (∼70% of the cells change as indexed by Arc). Learning and memory modified rewarded odor ensembles to increase stability in a core representational component.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.