ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Olfactory aversive conditioning during sleep reduces cigarette-smoking behavior.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- A Systematic Review of Closed-Loop Feedback Techniques in Sleep Studies-Related Issues and Future Directions.Sensors (Basel, Switzerland) · 2020Pooled it
- Promoting memory consolidation during sleep: A meta-analysis of targeted memory reactivation.Psychological bulletin · 2020Pooled it
- Efficacy and mechanisms of repeated closed-loop auditory exposure during slow-wave sleep for internet gaming disorder.Molecular psychiatry · 2025Trial
- Pleasant olfactory cues can reduce cigarette craving.Journal of abnormal psychology · 2019Trial
- Lack of frequency-tagged magnetic responses suggests statistical regularities remain undetected during NREM sleep.Scientific reports · 2018Trial
- Respiration-triggered olfactory stimulation reduces obstructive sleep apnea severity: A prospective pilot study.Journal of sleep research · 2024Article
- The Interactions between Smoking and Sleep.Biomedicines · 2024Review
- Article
- What Does the Human Olfactory System Do, and How Does It Do It?Annual review of psychology · 2024Review
- Behavioral and brain responses to verbal stimuli reveal transient periods of cognitive integration of the external world during sleep.Nature neuroscience · 2023Article
- Conditioning of the Cortisol Awakening Response in Healthy Men: Study Protocol for a Randomized Controlled Trial.JMIR research protocols · 2023Article
- Updating memories of unwanted emotions during human sleep.Current biology : CB · 2023Article
- State-dependent olfactory processing in freely behaving mice.Cell reports · 2022Article
- Exposure to Olfactory Alcohol Cues During Non-rapid Eye Movement Sleep Did Not Decrease Craving in Patients With Alcohol Dependence.Frontiers in psychiatry · 2022Article
- Development and Study of Ezzence: A Modular Scent Wearable to Improve Wellbeing in Home Sleep Environments.Frontiers in psychology · 2022Article
- Learning New Vocabulary Implicitly During Sleep Transfers With Cross-Modal Generalization Into Wakefulness.Frontiers in neuroscience · 2022Article
- Drug addiction - How it hijacks our cognition & consciousness.The Indian journal of medical research · 2021Article
- Memory and Sleep: How Sleep Cognition Can Change the Waking Mind for the Better.Annual review of psychology · 2021Article
- Dormio: A targeted dream incubation device.Consciousness and cognition · 2020Article
- Dream engineering: Simulating worlds through sensory stimulation.Consciousness and cognition · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent findings suggest that novel associations can be learned during sleep. However, whether associative learning during sleep can alter later waking behavior and whether such behavioral changes last for minutes, hours, or days remain unknown. We tested the hypothesis that olfactory aversive conditioning during sleep will alter cigarette-smoking behavior during ensuing wakefulness. A total of 66 human subjects wishing to quit smoking participated in the study (23 females; mean age, 28.7 ± 5.2 years). Subjects completed a daily smoking diary detailing the number of cigarettes smoked during 7 d before and following a 1 d or night protocol of conditioning between cigarette odor and profoundly unpleasant odors. We observed significant reductions in the number of cigarettes smoked following olfactory aversive conditioning during stage 2 and rapid eye movement (REM) sleep but not following aversive conditioning during wakefulness (p < 0.05). Moreover, the reduction in smoking following aversive conditioning during stage 2 (34.4 ± 30.1%) was greater and longer lasting compared with the reduction following aversive conditioning during REM (11.9 ± 19.2%, p < 0.05). Finally, the reduction in smoking following aversive conditioning during sleep was significantly greater than in two separate control sleep experiments that tested aversive odors alone and the effects of cigarette odors and aversive odors without pairing. To conclude, a single night of olfactory aversive conditioning during sleep significantly reduced cigarette-smoking behavior in a sleep stage-dependent manner, and this effect persisted for several days.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.