Evidence map›Paper›PMID 25392486›Full record

ReviewThe Journal of neuroscience : the official journal of the Society for Neuroscience2014

New roles for the external globus pallidus in basal ganglia circuits and behavior.

Aryn H Gittis, Joshua D Berke, Mark D Bevan, C Savio Chan, Nicolas Mallet, Michelle M Morrow, Robert Schmidt

Abstract readReview
In one paragraph

Review in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed.

  1. Article
  2. Indirect Striatal Projection Neurons Drive a D2 Receptor-Dependent Pathway to Dyskinesia and Dystonia.Movement disorders : official journal of the Movement Disorder Society · 2026
    Article
  3. Article
  4. Article
  5. Reciprocal projections between the globus pallidus externa and cortex span motor and nonmotor regions.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Arkypallidal neurons in the external globus pallidus can mediate inhibitory control by altering competition in the striatum.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aryn H GittisDepartment of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, agittis@cmu.edu.ORCID http://orcid.org/0000-0002-3591-5775
Joshua D BerkeDepartment of Psychology, Department of Biomedical Engineering, and Neuroscience Program, University of Michigan, Ann Arbor, Michigan 48109.ORCID http://orcid.org/0000-0003-2904-4384
Mark D BevanDepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 48109.
C Savio ChanDepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 48109.
Nicolas MalletInstitut des maladies neurodégénératives, CNRS UMR 5293, Université de Bordeaux, 33076 Bordeaux, France.
Michelle M MorrowCenter for the Neural Basis of Cognition and Systems Neuroscience Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, and.ORCID http://orcid.org/0000-0001-9475-0934
Robert SchmidtBrainLinks-BrainTools, Bernstein Center Freiburg, University of Freiburg, Freiburg 79085, Germany.

Funding

SYNAPTIC CONTROLOF PALLIDAL ACTIVITYP50NS047085 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SURMEIER, DALTON JAMES · 2003 to 2018
$19.2M
ResourceP40OD010996 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STRICK, PETER · 2012 to 2024
$11.0M
CENTER FOR NEUROANATOMY WITH NEUROTROPIC VIRUSES: COMPARATIVE MEDICINEP40RR018604 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STRICK, PETER · 2004 to 2011
$6.5M
BASAL GANGLIA, CEREBELLUM AND HIGHER CORTICAL FUNCTIONR01MH056661 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STRICK, PETER · 1997 to 2012
$4.0M
Striatopallidal GABAergic Signaling in Mouse Models of Parkinson's DiseaseR01NS069777 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CHAN, SAVIO · 2010 to 2021
$3.9M
Synaptic Transmission, Plasticity and Integration in the Subthalamic NucleusR37NS041280 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BEVAN, MARK D · 2012 to 2018
$2.7M
Striatal Microcircuits: Regulation and FunctionR01NS078435 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BERKE, JOSHUA D, KREITZER, ANATOL · 2012 to 2016
$2.4M
Training in the Neurobiology of Neurodegenerative DiseaseT32NS007391 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZIGMOND, MICHAEL J · 1997 to 2013
$2.3M
Basal Ganglia Pathways for Stopping and SwitchingR01MH101697 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BERKE, JOSHUA D · 2013 to 2017
$1.9M
Surgery Core - NINDS Institutional Core Grants to Support Neuroscience ResearchP30NS076405 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STRICK, PETER · 2012 to 2016
$1.8M
Organization and Function of Striatal Microcircuits in Health and DiseaseR00NS076524 · NINDS · CARNEGIE-MELLON UNIVERSITY · PI GITTIS, ARYN HILARY · 2013 to 2015
$736k
Combining optogenetics and electrophysiology to dissect accumbens microcircuitsR21MH093888 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BERKE, JOSHUA D · 2011 to 2012
$427k
NCRR NIH HHS P40 RR018604NCRR NIH HHS P40RR018604NIDA NIH HHS R21 DA032259NIDA NIH HHS R21DA032259NIH HHS P40 OD010996NIMH NIH HHS F32 MH080569NIMH NIH HHS F32MH080569NIMH NIH HHS R01 MH056661NIMH NIH HHS R01 MH101697NIMH NIH HHS R01MH101697NIMH NIH HHS R01MH56661NIMH NIH HHS R21 MH093888NIMH NIH HHS R21MH093888NINDS NIH HHS NS047085NINDS NIH HHS P30 NS076405NINDS NIH HHS P30NS076405NINDS NIH HHS P50 NS047085NINDS NIH HHS P50NS047085NINDS NIH HHS R00 NS076524NINDS NIH HHS R00NS076524NINDS NIH HHS R01 NS069777NINDS NIH HHS R01NS069777NINDS NIH HHS R01NS069777-S1NINDS NIH HHS R01 NS078435NINDS NIH HHS R01NS078435NINDS NIH HHS R37 NS041280NINDS NIH HHS R37NS041280NINDS NIH HHS T32 NS007391NINDS NIH HHS TS32NS07391PHS HHS P40ODO10996
6 · The paper itself

Abstract

The development of methodology to identify specific cell populations and circuits within the basal ganglia is rapidly transforming our ability to understand the function of this complex circuit. This mini-symposium highlights recent advances in delineating the organization and function of neural circuits in the external segment of the globus pallidus (GPe). Although long considered a homogeneous structure in the motor-suppressing "indirect-pathway," the GPe consists of a number of distinct cell types and anatomical subdomains that contribute differentially to both motor and nonmotor features of behavior. Here, we integrate recent studies using techniques, such as viral tracing, transgenic mice, electrophysiology, and behavioral approaches, to create a revised framework for understanding how the GPe relates to behavior in both health and disease.

Indexed as

AnimalsBasal GangliaCorpus StriatumGlobus PallidusHumansNeural PathwaysNeurogliaNeuronsParkinson Disease

Identifiers

PMID25392486
PMCPMC4228126

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.