ArticleProceedings. Biological sciences2015
Reactive vaccination in the presence of disease hotspots.
Article in Proceedings. Biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Spatiotemporal trends of foot and mouth disease (FMD) in Bangladesh from 2017 to 2023 and their associations with climatic factors and machine learning (ML) based prediction.Scientific reports · 2026Article
- A proposed One Health approach to control yellow fever outbreaks in Uganda.One health outlook · 2024Review
- Cost-effectiveness analysis of typhoid conjugate vaccines in an outbreak setting: a modeling study.BMC infectious diseases · 2023Article
- Modeling a sustainable vaccine supply chain for a healthcare system.Journal of cleaner production · 2022Article
- Projecting vaccine demand and impact for emerging zoonotic pathogens.BMC medicine · 2022Article
- Optimizing Spatio-Temporal Allocation of the COVID-19 Vaccine Under Different Epidemiological Landscapes.Frontiers in public health · 2022Article
- Optimizing Spatial Allocation of COVID-19 Vaccine by Agent-Based Spatiotemporal Simulations.GeoHealth · 2021Article
- Protection afforded by previous Vibrio cholerae infection against subsequent disease and infection: A review.PLoS neglected tropical diseases · 2021Review
- Critical spatial clusters for vaccine preventable diseases.Social, cultural, and behavioral modeling : 13th International Conference, SBP-BRiMS 2020, Washington, DC, USA, October 18-21, 2020, Proceedings. International Conference on Social Computing Behavioral-Cultural Modeling, and Prediction ... · 2020Article
- Foot-and-Mouth Disease Space-Time Clusters and Risk Factors in Cattle and Buffalo in Bangladesh.Pathogens (Basel, Switzerland) · 2020Article
- Ecological drivers of African swine fever virus persistence in wild boar populations: Insight for control.Ecology and evolution · 2020Article
- Migration, hotspots, and dispersal of HIV infection in Rakai, Uganda.Nature communications · 2020Article
- A theoretical single-parameter model for urbanisation to study infectious disease spread and interventions.PLoS computational biology · 2019Article
- Predicting vaccine effectiveness in livestock populations: A theoretical framework applied to PRRS virus infections in pigs.PloS one · 2019Article
- The Epidemiology of Cholera in Zanzibar: Implications for the Zanzibar Comprehensive Cholera Elimination Plan.The Journal of infectious diseases · 2018Article
- Best practice assessment of disease modelling for infectious disease outbreaks.Epidemiology and infection · 2018Review
- The potential impact of case-area targeted interventions in response to cholera outbreaks: A modeling study.PLoS medicine · 2018Article
- River networks as ecological corridors: A coherent ecohydrological perspective.Advances in water resources · 2018Article
- Prolonging herd immunity to cholera via vaccination: Accounting for human mobility and waning vaccine effects.PLoS neglected tropical diseases · 2018Article
- Sylvatic Plague Vaccine Partially Protects Prairie Dogs (Cynomys spp.) in Field Trials.EcoHealth · 2017Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reactive vaccination has recently been adopted as an outbreak response tool for cholera and other infectious diseases. Owing to the global shortage of oral cholera vaccine, health officials must quickly decide who and where to distribute limited vaccine. Targeted vaccination in transmission hotspots (i.e. areas with high transmission efficiency) may be a potential approach to efficiently allocate vaccine, however its effectiveness will likely be context-dependent. We compared strategies for allocating vaccine across multiple areas with heterogeneous transmission efficiency. We constructed metapopulation models of a cholera-like disease and compared simulated epidemics where: vaccine is targeted at areas of high or low transmission efficiency, where vaccine is distributed across the population, and where no vaccine is used. We find that connectivity between populations, transmission efficiency, vaccination timing and the amount of vaccine available all shape the performance of different allocation strategies. In highly connected settings (e.g. cities) when vaccinating early in the epidemic, targeting limited vaccine at transmission hotspots is often optimal. Once vaccination is delayed, targeting the hotspot is rarely optimal, and strategies that either spread vaccine between areas or those targeted at non-hotspots will avert more cases. Although hotspots may be an intuitive outbreak control target, we show that, in many situations, the hotspot-epidemic proceeds so fast that hotspot-targeted reactive vaccination will prevent relatively few cases, and vaccination shared across areas where transmission can be sustained is often best.
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