ArticleThe Journal of experimental biology2014
Mechanisms of naturally evolved ethanol resistance in Drosophila melanogaster.
Article in The Journal of experimental biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Alternative 3' Polyadenylation Responses to Acute Ethanol Exposure Differ Between Drosophila Populations.Research square · 2026Article
- Cosmopolitan inversions have a major impact on trait variation and the power of different GWAS approaches to identify associations.PLoS genetics · 2026Article
- Tolerance and efficient metabolization of extremely high ethanol concentrations by a social wasp.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Microbiome-by-ethanol interactions impact Drosophila melanogaster fitness, physiology, and behavior.iScience · 2022Article
- Ethanol resistance inEcology and evolution · 2021Article
- A vertebrate adaptive radiation is assembled from an ancient and disjunct spatiotemporal landscape.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- How gut microbiome interactions affect nutritional traits ofThe Journal of experimental biology · 2020Article
- Different genetic basis for alcohol dehydrogenase activity and plasticity in a novel alcohol environment for Drosophila melanogaster.Heredity · 2020Article
- Fitness effects but no temperature-mediated balancing selection at the polymorphicProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Human alcohol dehydrogenase 1 is an acceptor protein for polyADP-ribosylation.Biochemical pharmacology · 2019Article
- Population-specific dynamics and selection patterns of transposable element insertions in European natural populations.Molecular ecology · 2019Article
- Effects of a low dose of ethanol on mating success ofEntomologia experimentalis et applicata · 2018Article
- GCY-35/GCY-36-TAX-2/TAX-4 Signalling in OScientific reports · 2018Article
- Conservation of social effects (ΨEcology and evolution · 2017Article
- Experimental test and refutation of a classic case of molecular adaptation in Drosophila melanogaster.Nature ecology & evolution · 2017Article
- Preference for ethanol in feeding and oviposition in temperate and tropical populations ofEntomologia experimentalis et applicata · 2015Article
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Authors and funding
1 author at 1 institution in 1 country.
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Abstract
The decaying fruit in which Drosophila melanogaster feed and breed can contain ethanol in concentrations as high as 6-7%. In this cosmopolitan species, populations from temperate regions are consistently more resistant to ethanol poisoning than populations from the tropics, but little is known about the physiological basis of this difference. I show that when exposed to low levels of ethanol vapor, flies from a tropical African population accumulated 2-3 times more internal ethanol than flies from a European population, giving evidence that faster ethanol catabolism by European flies contributes to the resistance difference. Using lines differing only in the origin of their third chromosome, however, I show that faster ethanol elimination cannot fully explain the resistance difference, because relative to African third chromosomes, European third chromosomes confer substantially higher ethanol resistance, while having little effect on internal ethanol concentrations. European third chromosomes also confer higher resistance to acetic acid, a metabolic product of ethanol, than African third chromosomes, suggesting that the higher ethanol resistance conferred by the former might be due to increased resistance to deleterious effects of ethanol-derived acetic acid. In support of this hypothesis, when ethanol catabolism was blocked with an Alcohol dehydrogenase mutant, there was no difference in ethanol resistance between flies with European and African third chromosomes.
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