Evidence map›Paper›PMID 25392425›Full record

ArticleNucleic acids research2015

Rfam 12.0: updates to the RNA families database.

Eric P Nawrocki, Sarah W Burge, Alex Bateman, Jennifer Daub, Ruth Y Eberhardt, Sean R Eddy, Evan W Floden, Paul P Gardner, Thomas A Jones, John Tate and 1 more

Abstract read
In one paragraph

Article in Nucleic acids research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 658 papers.

0numbers the graph read from it
0cells of the map it votes in
658citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

658 citing papers in PubMed.

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  14. ARNA (New York, N.Y.) · 2026
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  18. Microbiome TherapeuticJournal of microbiology and biotechnology · 2025
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  20. Pharmaceutics · 2025
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598 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Eric P NawrockiHHMI Janelia Farm Research Campus, Ashburn, VA, USA.
Sarah W BurgeEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
Alex BatemanEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
Jennifer DaubEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
Ruth Y EberhardtEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
Sean R EddyHHMI Janelia Farm Research Campus, Ashburn, VA, USA.
Evan W FlodenEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
Paul P GardnerBiomolecular Interaction Centre, School of Biological Sciences, University of Canterbury, Christchurch, New Zealand.ORCID http://orcid.org/0000-0002-7808-1213
Thomas A JonesHHMI Janelia Farm Research Campus, Ashburn, VA, USA.
John TateEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
Robert D FinnHHMI Janelia Farm Research Campus, Ashburn, VA, USA European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, UK rdf@ebi.ac.uk.

Funding

Howard Hughes Medical InstituteWellcome Trust WT098051
6 · The paper itself

Abstract

The Rfam database (available at http://rfam.xfam.org) is a collection of non-coding RNA families represented by manually curated sequence alignments, consensus secondary structures and annotation gathered from corresponding Wikipedia, taxonomy and ontology resources. In this article, we detail updates and improvements to the Rfam data and website for the Rfam 12.0 release. We describe the upgrade of our search pipeline to use Infernal 1.1 and demonstrate its improved homology detection ability by comparison with the previous version. The new pipeline is easier for users to apply to their own data sets, and we illustrate its ability to annotate RNAs in genomic and metagenomic data sets of various sizes. Rfam has been expanded to include 260 new families, including the well-studied large subunit ribosomal RNA family, and for the first time includes information on short sequence- and structure-based RNA motifs present within families.

Indexed as

Databases, Nucleic AcidGenomicsInternetMolecular Sequence AnnotationNucleic Acid ConformationNucleotide MotifsRNA, Long NoncodingRNA, UntranslatedSoftwareRNA, Long NoncodingRNA, Untranslated

Identifiers

PMID25392425
PMCPMC4383904

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.