ArticleJournal of the Royal Society, Interface2015
Evolution on neutral networks accelerates the ticking rate of the molecular clock.
Article in Journal of the Royal Society, Interface, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Non-Poissonian Bursts in the Arrival of Phenotypic Variation Can Strongly Affect the Dynamics of Adaptation.Molecular biology and evolution · 2024Article
- The Boltzmann distributions of molecular structures predict likely changes through random mutations.Biophysical journal · 2023Article
- Physics of diffusion in viral genome evolution.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Insertions and deletions in the RNA sequence-structure map.Journal of the Royal Society, Interface · 2021Article
- Phase transitions and assortativity in models of gene regulatory networks evolved under different selection processes.Journal of the Royal Society, Interface · 2021Article
- Neutral components show a hierarchical community structure in the genotype-phenotype map of RNA secondary structure.Journal of the Royal Society, Interface · 2020Article
- Using small samples to estimate neutral component size and robustness in the genotype-phenotype map of RNA secondary structure.Journal of the Royal Society, Interface · 2020Article
- Biophysics and population size constrains speciation in an evolutionary model of developmental system drift.PLoS computational biology · 2019Article
- Article
- On the networked architecture of genotype spaces and its critical effects on molecular evolution.Open biology · 2018Review
- The architecture of an empirical genotype-phenotype map.Evolution; international journal of organic evolution · 2018Article
- Information theory, evolutionary innovations and evolvability.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
- The space of genotypes is a network of networks: implications for evolutionary and extinction dynamics.Scientific reports · 2017Article
- Internal Disequilibria and Phenotypic Diversification during Replication of Hepatitis C Virus in a Noncoevolving Cellular Environment.Journal of virology · 2017Article
- Adaptive multiscapes: an up-to-date metaphor to visualize molecular adaptation.Biology direct · 2017Article
- Percolation in protein sequence space.PloS one · 2017Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Large sets of genotypes give rise to the same phenotype, because phenotypic expression is highly redundant. Accordingly, a population can accept mutations without altering its phenotype, as long as the genotype mutates into another one on the same set. By linking every pair of genotypes that are mutually accessible through mutation, genotypes organize themselves into neutral networks (NNs). These networks are known to be heterogeneous and assortative, and these properties affect the evolutionary dynamics of the population. By studying the dynamics of populations on NNs with arbitrary topology, we analyse the effect of assortativity, of NN (phenotype) fitness and of network size. We find that the probability that the population leaves the network is smaller the longer the time spent on it. This progressive 'phenotypic entrapment' entails a systematic increase in the overdispersion of the process with time and an acceleration in the fixation rate of neutral mutations. We also quantify the variation of these effects with the size of the phenotype and with its fitness relative to that of neighbouring alternatives.
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