Evidence map›Paper›PMID 25392187›Full record

Trial reportAmerican journal of Alzheimer's disease and other dementias2015

Testosterone treatment of men with mild cognitive impairment and low testosterone levels.

M M Cherrier, K Anderson, J Shofer, S Millard, A M Matsumoto

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of Alzheimer's disease and other dementias, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 4 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 70 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. [Testosterone and Alzheimer's disease].Problemy endokrinologii · 2022
    Article
  14. Impact of Testosterone on Alzheimer's Disease.The world journal of men's health · 2022
    Review
  15. Review
  16. Article
  17. Testosterone replacement and improved memory.Canadian family physician Medecin de famille canadien · 2021
    Article
  18. Review
  19. Review
  20. Sex-dependent effect ofDisease models & mechanisms · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

M M CherrierDepartment of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA cherrier@uw.edu.
K AndersonDepartment of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA.
J ShoferGeriatric, Research, Education and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, USA.
S MillardGeriatric, Research, Education and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, USA.
A M MatsumotoGeriatric, Research, Education and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, USA Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA.
Geriatric Research Education and Clinical Center · USUniversity of Washington · USVA Puget Sound Health Care System · US

Funding

Testosterone Supplementation in Men with MCIR01AG027156 · NIA · UNIVERSITY OF WASHINGTON · PI CHERRIER, MONIQUE · 2007 to 2009
$951k
NIA NIH HHS AG027156NIA NIH HHS R01 AG027156
6 · The paper itself

Abstract

introductionThis study investigated the effects of testosterone (T) treatment on cognition, mood, and quality of life in men with mild cognitive impairment (MCI) and low serum T levels.

methodsA total of 351 community-dwelling men were screened, and 37 men evidenced both MCI and low T of whom 27 agreed for further screening. Twenty-two met all the study inclusion/exclusion criteria and enrolled in a 6-month randomized, double-blind, placebo-controlled study.

resultsTotal T levels significantly increased in the T treatment group. No significant changes were observed in measures of cognition, mood, or quality of life other than improvement in 1 objective measure of verbal memory (P < .05) and decreased depression symptoms (P < .02) in the treatment group.

conclusionsTestosterone treatment may modestly improve verbal memory and depression symptoms in men with both MCI and low T.

Indexed as

Quality of LifeAgedAged, 80 and overCognitive DysfunctionDepressionDouble-Blind MethodHumansMaleMemoryMiddle AgedTestosteroneTreatment OutcomeTestosteronecognitionlow serum testosteronemild cognitive impairmentquality of lifetestosterone treatmentverbal memory

Identifiers

PMID25392187
PMCPMC10852633
OpenAlexW2007340922

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.