ArticleJournal of neurophysiology2015
Neocortical inhibitory activities and long-range afferents contribute to the synchronous onset of silent states of the neocortical slow oscillation.
Article in Journal of neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed, 56 citations in OpenAlex.
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- Sleep restoration by optogenetic targeting of GABAergic neurons reprograms microglia and ameliorates pathological phenotypes in an Alzheimer's disease model.Molecular neurodegeneration · 2023Article
- Diversity of cortical activity changes beyond depression during Spreading Depolarizations.Nature communications · 2023Article
- Stimulus Feature-Specific Control of Layer 2/3 Subthreshold Whisker Responses by Layer 4 in the Mouse Primary Somatosensory Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Breathing coordinates cortico-hippocampal dynamics in mice during offline states.Nature communications · 2022Article
- Spontaneous slow oscillation-slow spindle features predict induced overnight memory retention.Sleep · 2021Article
- Somatostatin interneurons activated by 5-HTeLife · 2021Article
- Cortical astrocytes independently regulate sleep depth and duration via separate GPCR pathways.eLife · 2021Article
- Ethanol Alters Variability, But Not Rate, of Firing in Medial Prefrontal Cortex Neurons of Awake-Behaving Rats.Alcoholism, clinical and experimental research · 2020Article
- Article
- Modulation of cortical slow oscillatory rhythm by GABAThe Journal of physiology · 2020Article
- The claustrum coordinates cortical slow-wave activity.Nature neuroscience · 2020Article
- Global control of sleep slow wave activity.Nature neuroscience · 2020Article
- Spatio-temporal properties of sleep slow waves and implications for development.Current opinion in physiology · 2020Article
- Slow Wave Sleep Is a Promising Intervention Target for Alzheimer's Disease.Frontiers in neuroscience · 2020Review
- Thalamic Drive of Cortical Parvalbumin-Positive Interneurons during Down States in Anesthetized Mice.Current biology : CB · 2019Article
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3 authors at 2 institutions in 1 country.
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Abstract
During slow-wave sleep, neurons of the thalamocortical network are engaged in a slow oscillation (<1 Hz), which consists of an alternation between the active and the silent states. Several studies have provided insights on the transition from the silent, which are essentially periods of disfacilitation, to the active states. However, the conditions leading to the synchronous onset of the silent state remain elusive. We hypothesized that a synchronous input to local inhibitory neurons could contribute to the transition to the silent state in the cat suprasylvian gyrus during natural sleep and under ketamine-xylazine anesthesia. After partial and complete deafferentation of the cortex, we found that the silent state onset was more variable among remote sites. We found that the transition to the silent state was preceded by a reduction in excitatory postsynaptic potentials and firing probability in cortical neurons. We tested the impact of chloride-mediated inhibition in the silent-state onset. We uncovered a long-duration (100-300 ms) inhibitory barrage occurring about 250 ms before the silent state onset in 3-6% of neurons during anesthesia and in 12-15% of cases during natural sleep. These inhibitory activities caused a decrease in cortical firing that reduced the excitatory drive in the neocortical network. That chain reaction of disfacilitation ends up on the silent state. Electrical stimuli could trigger a network silent state with a maximal efficacy in deep cortical layers. We conclude that long-range afferents to the neocortex and chloride-mediated inhibition play a role in the initiation of the silent state.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.