ArticleJournal of neurophysiology2015
Related neuropeptides use different balances of unitary mechanisms to modulate the cardiac neuromuscular system in the American lobster, Homarus americanus.
Article in Journal of neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- HyPep: An Open-Source Software for Identification and Discovery of Neuropeptides Using Sequence Homology Search.Journal of proteome research · 2023Article
- The role of feedback and modulation in determining temperature resiliency in the lobster cardiac nervous system.Frontiers in neuroscience · 2023Article
- Localization of chemical synapses and modulatory release sites in the cardiac ganglion of the crab, Cancer borealis.The Journal of comparative neurology · 2022Article
- Structural variation between neuropeptide isoforms affects function in the lobster cardiac system.General and comparative endocrinology · 2022Article
- Neuropeptidomic Profiling and Localization in the Crustacean Cardiac Ganglion Using Mass Spectrometry Imaging with Multiple Platforms.Journal of the American Society for Mass Spectrometry · 2020Article
- Cloning of the first cDNA encoding a putative CCRFamide precursor: identification of the brain, eyestalk ganglia, and cardiac ganglion as sites of CCRFamide expression in the American lobster, Homarus americanus.Invertebrate neuroscience : IN · 2020Article
- SIFamide peptides modulate cardiac activity differently in two species of Cancer crab.General and comparative endocrinology · 2019Article
- To what extent may peptide receptor gene diversity/complement contribute to functional flexibility in a simple pattern-generating neural network?Comparative biochemistry and physiology. Part D, Genomics & proteomics · 2019Article
- AMGSEFLamide, a member of a broadly conserved peptide family, modulates multiple neural networks inThe Journal of experimental biology · 2019Article
- A review of the actions of Nitric Oxide in development and neuronal function in major invertebrate model systems.AIMS neuroscience · 2019Review
- Three members of a peptide family are differentially distributed and elicit differential state-dependent responses in a pattern generator-effector system.Journal of neurophysiology · 2018Article
- The neural control of heartbeat in invertebrates.Current opinion in neurobiology · 2016Review
- Neuropeptide modulation of pattern-generating systems in crustaceans: comparative studies and approaches.Current opinion in neurobiology · 2016Review
- Forces generated during stretch in the heart of the lobster Homarus americanus are anisotropic and are altered by neuromodulators.The Journal of experimental biology · 2016Article
- Characterizing the physiological and behavioral roles of proctolin in Drosophila melanogaster.Journal of neurophysiology · 2016Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
To produce flexible outputs, neural networks controlling rhythmic motor behaviors can be modulated at multiple levels, including the pattern generator itself, sensory feedback, and the response of the muscle to a given pattern of motor output. We examined the role of two related neuropeptides, GYSDRNYLRFamide (GYS) and SGRNFLRFamide (SGRN), in modulating the neurogenic lobster heartbeat, which is controlled by the cardiac ganglion (CG). When perfused though an isolated whole heart at low concentrations, both peptides elicited increases in contraction amplitude and frequency. At higher concentrations, both peptides continued to elicit increases in contraction amplitude, but GYS caused a decrease in contraction frequency, while SGRN did not alter frequency. To determine the sites at which these peptides induce their effects, we examined the effects of the peptides on the periphery and on the isolated CG. When we removed the CG and stimulated the motor nerve with constant bursts of stimuli, both GYS and SGRN increased contraction amplitude, indicating that each peptide modulates the muscle or the neuromuscular junction. When applied to the isolated CG, neither peptide altered burst frequency at low peptide concentrations; at higher concentrations, SGRN decreased burst frequency, whereas GYS continued to have no effect on frequency. Together, these data suggest that the two peptides elicit some of their effects using different mechanisms; in particular, given the known feedback pathways within this system, the importance of the negative (nitric oxide) relative to the positive (stretch) feedback pathways may differ in the presence of the two peptides.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.