ArticleBritish journal of cancer1989
Immunohistochemical localisation of tissue plasminogen activator in human brain tumours.
Article in British journal of cancer, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 19 citations in OpenAlex.
- Modulation of tissue-type plasminogen activator expression by platelet activating factor in human glioma cells.Journal of neuro-oncology · 2002Article
- Prognostic role of urokinase-type plasminogen activator in human gliomas.The American journal of pathology · 1995Article
- Inhibition of tumor necrosis factor-alpha and -beta secretion by lymphokine activated killer cells by transforming growth factor-beta.Japanese journal of cancer research : Gann · 1994Article
- Prognostic significance of proteolytic enzymes in human brain tumors.Journal of neuro-oncology · 1994Review
- The hemostatic system and angiogenesis in malignancy.Neoplasia (New York, N.Y.)Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
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Abstract
The distribution of tissue plasminogen activator (t-PA) has been studied in a series of 38 human brain tumours and two specimens of cerebral cortex, using the monoclonal antibody ESP6. t-PA was localised in vascular endothelium in the majority of tumours and both the cortical specimens, confirmed by double staining with Ulex europaeus lectin (Uel) and Factor 8-related antigen. Nineteen out of 22 high grade astrocytomas showed strong endothelial staining whereas staining was weak or absent in the four low grade astrocytomas studied. No consistent relationship was found between the pattern of staining and tumour grade in the other tumours, although strong staining of the three metastatic lesions with Uel was observed. Among the astroglial tumours only one glioblastoma showed any tumour cell staining for t-PA, which raises questions concerning the origin of t-PA producing cells derived from human gliomas in vitro. Studies of t-PA in brain tumours should take account of this vascular localisation before concluding that the activity is derived from neoplastic cells.
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