ArticleJournal of the International AIDS Society2014
Predictors of liver-related death among people who inject drugs in Vancouver, Canada: a 15-year prospective cohort study.
Article in Journal of the International AIDS Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- The impact of methadone maintenance therapy on access to regular physician care regarding hepatitis C among people who inject drugs.PloS one · 2018Trial
- Public health interventions, priority populations, and the impact of COVID-19 disruptions on hepatitis C elimination among people who have injected drugs in Montreal (Canada): A modeling study.The International journal on drug policy · 2023Article
- Heroin use is associated with liver fibrosis in the Miami Adult Studies on HIV (MASH) cohort.Drug and alcohol dependence · 2021Article
- Elimination of HCV as a public health concern among people who inject drugs by 2030 - What will it take to get there?Journal of the International AIDS Society · 2017Article
- HIV treatment as prevention among people who inject drugs - a re-evaluation of the evidence.International journal of epidemiology · 2017Article
- Reducing rates of preventable HIV/AIDS-associated mortality among people living with HIV who inject drugs.Current opinion in HIV and AIDS · 2016Review
- Impact of hepatitis C status on 20-year mortality of patients with substance use disorders.Addiction science & clinical practice · 2015Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
introductionWhile HIV/AIDS remains an important cause of death among people who inject drugs (PWID), the potential mortality burden attributable to hepatitis C virus (HCV) infection among this population is of increasing concern. Therefore, we sought to identify trends in and predictors of liver-related mortality among PWID.
methodsData were derived from prospective cohorts of PWID in Vancouver, Canada, between 1996 and 2011. Cohort data were linked to the provincial vital statistics database to ascertain mortality rates and causes of death. Multivariate Cox proportional hazards regression was used to examine the relationship between HCV infection and time to liver-related death. A sub-analysis examined the effect of HIV/HCV co-infection. RESULTS AND DISCUSSION: In total, 2,279 PWID participated in this study, with 1,921 (84.3%) having seroconverted to anti-HCV prior to baseline assessments and 124 (5.4%) during follow-up. The liver-related mortality rate was 2.1 (95% confidence interval [CI]: 1.5-3.0) deaths per 1,000 person-years and was stable over time. In multivariate analyses, HCV seropositivity was not significantly associated with liver-related mortality (adjusted relative hazard [ARH]: 0.45; 95% CI: 0.15-1.37), but HIV seropositivity was (ARH: 2.67; 95% CI: 1.27-5.63). In sub-analysis, HIV/HCV co-infection had a 2.53 (95% CI: 1.18-5.46) times hazard of liver-related death compared with HCV mono-infection.
conclusionsIn this study, HCV seropositivity did not predict liver-related mortality while HIV seropositivity did. The findings highlight the critical role of HIV mono- and co-infection rather than HCV infection in contributing to liver-related mortality among PWID in this setting.
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